Deoxycholic Acid Could Induce Apoptosis and Trigger Gastric Carcinogenesis on Gastric Epithelial Cells by Quantitative Proteomic Analysis
Table 2
Upregulated proteins in GES-1 cells treated with deoxycholic acid (ratio > 5).
Number
Protein name
pI
Nominal mass
Protein function
1
Cell cycle control protein 50A
5.917
8.81
40683
Not clear
2
UPF0428 protein CXorf56
11.628
8.94
25624
Not clear
3
ATP synthase mitochondrial F1 complex assembly factor 2
7.092
6.62
32772
May play a role in the assembly of the F1 component of the mitochondrial ATP synthase (ATPase)
4
snRNA-activating protein complex subunit 4
8.547
8.51
159432
Part of the SNAPc complex required for the transcription of both RNA polymerase II and polymerase III small-nuclear RNA genes
5
N-chimaerin
6.098
6.51
53172
GTPase-activating protein for p21-rac and a phorbol ester receptor, involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance
6
Son of sevenless homolog 1
5.155
6.38
152464
Promotes the exchange of Ras-bound GDP by GTP, catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity
7
Focal adhesion kinase 1
5.952
6.19
119233
Nonreceptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation, and apoptosis
8
Protein transport protein Sec61 subunit alpha isoform 1
7.143
8.3
52264
Plays a crucial role in the insertion of secretory and membrane polypeptides into the ER
of the specific value of expression intensity of the protein in cells treated with or without deoxycholic acid.
