Preoperative Serum Interleukin-6 Is a Potential Prognostic Factor for Colorectal Cancer, including Stage II Patients
Table 2
Results of the univariate analyses ().
High IL-6 levels (≥6.3 pg/mL) (%)
Low IL-6 levels (<6.3 pg/mL) (%)
value
Age (years)
≥75
24 (32.4)
50 (67.6)
0.07
<75
33 (20.8)
126 (79.2)
Sex
Female
20 (21.3)
74 (78.7)
0.44
Male
37 (26.6)
102 (73.4)
BMI
≥25
10 (19.2)
42 (80.8)
0.37
<25
47 (26.0)
134 (74.0)
Albumin (g/dL)
≥4.0
19 (14.4)
113 (85.6)
<0.01
<4.0
38 (37.6)
63 (62.4)
CRP (mg/dL)
≥0.5
34 (63.0)
20 (37.0)
<0.01
<0.5
23 (12.8)
156 (87.2)
CEA (ng/mL)
≥5.0
30 (32.3)
63 (67.7)
0.03
<5.0
27 (19.3)
113 (80.7)
CA19-9 (U/mL)
≥37.0
19 (38.0)
31 (62.0)
0.02
<37.0
38 (20.8)
145 (79.2)
VEGF (pg/mL)
≥145
12 (30.0)
28 (70.0)
0.42
<145
45 (23.3)
148 (76.7)
Tumor location
Right
24 (30.4)
55 (69.6)
0.15
Left
33 (21.4)
121 (78.6)
Pathological findings
Differentiation
Poor
6 (42.9)
8 (57.1)
0.11
Others
51 (23.3)
168 (76.7)
Lymphatic invasion
Positive
48 (26.4)
134 (73.6)
0.27
Negative
9 (17.6)
42 (82.4)
Venous invasion
Positive
50 (29.9)
117 (70.1)
<0.01
Negative
7 (10.6)
59 (89.4)
TNM classification
T
<4
28 (16.3)
144 (83.7)
<0.01
4
29 (47.5)
32 (52.5)
N
Positive
31 (30.4)
71 (69.6)
0.07
Negative
26 (19.8)
105 (80.2)
M
Positive
19 (42.2)
26 (57.8)
<0.01
Negative
28 (15.7)
150 (84.3)
Liver metastasis
Positive
11 (37.9)
18 (62.1)
0.27
Negative
46 (22.5)
158 (77.5)
Obstruction
Positive
23 (57.5)
17 (42.5)
<0.01
Negative
34 (17.6)
159 (82.4)
The analyses were performed using Fisher’s exact test. The results are presented as the number of patients. IL-6: interleukin-6; BMI: body mass index; CRP: C-reactive protein; CEA: carcinoembryonic antigen; CA19-9: carbohydrate antigen 19-9; VEGF: vascular endothelial growth factor.
