Review Article
Pretreatment Lymphocyte Monocyte Ratio Predicts Long-Term Outcomes in Patients with Digestive System Tumor: A Meta-Analysis
Table 2
Meta-analysis of HRs from univariate survival analysis.
| Outcome | Groups | Number of studies | Model | HR (95% CI) | (%) | Egger test |
| OS | All study | 18 | Fixed | 1.32 [1.28–1.36] | 0 | 0.156 | Tumor site | | | | | | Esophagus | 2 | Fixed | 1.35 [1.22–1.49] | 0 | | Stomach | 3 | Fixed | 1.27 [1.19–1.35] | 0 | | Colorectal | 9 | Fixed | 1.33 [1.28–1.39] | 0 | | Liver | 2 | Fixed | 1.67 [1.35–2.04] | 0 | | Pancreas | 2 | Fixed | 1.27 [1.12–1.43] | 0 | | Anatomic structure | | | | | | GT | 14 | Fixed | 1.32 [1.28–1.37] | 0 | | Non-GT | 4 | Fixed | 1.35 [1.22–1.49] | 44 | | Stage | | | | | | NMS | 9 | Fixed | 1.33 [1.28–1.39] | 0 | | Mixed | 3 | Fixed | 1.28 [1.19–1.37] | 0 | | MS | 6 | Fixed | 1.35 [1.25–1.45] | 10 | | Ethnicity | | | | | | Asian | 13 | Fixed | 1.32 [1.28–1.37] | 0 | | Non-Asian | 5 | Fixed | 1.33 [1.22–1.45] | 0 | | Cut-off value | | | | | | <3.0 | 8 | Fixed | 1.32 [1.27–1.39] | 0 | | ≥3.0 | 10 | Fixed | 1.32 [1.25–1.39] | 4 | | Treatment | | | | | | With surgery | 9 | Fixed | 1.32 [1.28–1.37] | 0 | | No surgery | 3 | Fixed | 1.33 [1.22–1.45] | 0 | |
| CSS | All study | 6 | Random | 1.35 [1.20–1.50] | 65 | 0.52 | Tumor site | | | | | | Colorectal | 3 | Fixed | 1.32 [1.18–1.47] | 29 | | Anatomic structure | | | | | | GT | 5 | Fixed | 1.39 [1.28–1.52] | 24 | | Stage | | | | | | Mixed | 2 | Random | 1.27 [1.04–1.54] | 70 | | MS | 3 | Fixed | 1.32 [1.18–1.47] | 29 | | Ethnicity | | | | | | Asian | 3 | Fixed | 1.49 [1.35–1.64] | 0 | | Non-Asian | 3 | Fixed | 1.21 [1.12–1.28] | 12 | | Cut-off value | | | | | | <3.0 | 3 | Random | 1.28 [1.11–1.49] | 80 | | ≥3.0 | 3 | Fixed | 1.47 [1.27–1.69] | 0 | |
| DFS/RFS | All study | 13 | Random | 1.26 [1.18–1.33] | 63 | 0.717 | Tumor site | | | | | | Stomach | 2 | Fixed | 1.22 [1.12–1.33] | 0 | | Colorectal | 7 | Fixed | 1.19 [1.11–1.28] | 46 | | Liver | 2 | Random | 1.39 [1.14–1.69] | 78 | | Anatomic structure | | | | | | GT | 10 | Fixed | 1.20 [1.18–1.25] | 29 | | Non-GT | 3 | Random | 1.41 [1.23–1.61] | 58 | | Stage | | | | | | NMS | 8 | Fixed | 1.22 [1.18–1.27] | 46 | | MS | 4 | Random | 1.23 [1.03–1.49] | 81 | | Ethnicity | | | | | | Asian | 9 | Random | 1.27 [1.18–1.35] | 71 | | Non-Asian | 4 | Fixed | 1.23 [1.12–1.37] | 32 | | Cut-off value | | | | | | <3.0 | 5 | Fixed | 1.27 [1.20–1.32] | 11 | | ≥3.0 | 8 | Random | 1.22 [1.12–1.33] | 73 | |
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HR: hazard ratio; CI: confidence interval; OS: overall survival; CSS: cancer-specific survival; DFS: disease-free survival; RFS: recurrence-free survival; GT: gastrointestinal tract; NMS: nonmetastatic stage; MS: metastatic stage.
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