Table of Contents Author Guidelines Submit a Manuscript
Gastroenterology Research and Practice
Volume 2017, Article ID 1654907, 6 pages
https://doi.org/10.1155/2017/1654907
Clinical Study

Efficacy and Safety of the Triple Therapy Containing Ilaprazole, Levofloxacin, and Amoxicillin as First-Line Treatment in Helicobacter pylori Infections

Division of Gastroenterology, Department of Internal Medicine, College of Medicine, Daejeon St. Mary’s Hospital, The Catholic University of Korea, Daejeon 34943, Republic of Korea

Correspondence should be addressed to Dong Soo Lee; rk.ca.cilohtac@2059jdcmc

Received 30 January 2017; Accepted 26 March 2017; Published 30 April 2017

Academic Editor: Spiros D. Ladas

Copyright © 2017 Hyo Jun Ahn et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. K. M. Fock, P. Katelaris, K. Sugano et al., “Second Asia-Pacific consensus guidelines for Helicobacter pylori infection,” Journal of Gastroenterology and Hepatology, vol. 24, no. 10, pp. 1587–1600, 2009. View at Publisher · View at Google Scholar · View at Scopus
  2. P. Malfertheiner, F. Megraud, C. A. O’Morain et al., “Management of Helicobacter pylori infection—the Maastricht IV/Florence consensus report,” Gut, vol. 61, no. 5, pp. 646–664, 2012. View at Publisher · View at Google Scholar · View at Scopus
  3. M. C. Chen, W. Y. Lei, J. S. Lin, C. H. Yi, D. C. Wu, and C. T. Hu, “Levofloxacin-amoxicillin/clavulanate-rabeprazole versus a standard seven-day triple therapy for eradication of Helicobacter pylori infection,” BioMed Research International, vol. 2014, Article ID 158520, p. 7, 2014. View at Publisher · View at Google Scholar · View at Scopus
  4. T. S. Wu, H. M. Hu, F. C. Kuo, and C. H. Kuo, “Eradication of Helicobacter pylori infection,” The Kaohsiung Journal of Medical Sciences, vol. 30, no. 4, pp. 167–172, 2014. View at Publisher · View at Google Scholar · View at Scopus
  5. M. Berning, S. Krasz, and S. Miehlke, “Should quinolones come first in Helicobacter pylori therapy?” Therapeutic Advances in Gastroenterology, vol. 4, no. 2, pp. 103–114, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. F. Zhao, J. Wang, Y. Yang et al., “Effect of CYP2C19 genetic polymorphisms on the efficacy of proton pump inhibitor-based triple therapy for Helicobacter pylori eradication: a meta-analysis,” Helicobacter, vol. 13, no. 6, pp. 532–541, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. H. Cho, M. K. Choi, D. Y. Cho et al., “Effect of CYP2C19 genetic polymorphism on pharmacokinetics and pharmacodynamics of a new proton pump inhibitor, ilaprazole,” Journal of Clinical Pharmacology, vol. 52, no. 7, pp. 976–984, 2012. View at Publisher · View at Google Scholar · View at Scopus
  8. J. S. Shin, J. Y. Lee, K. H. Cho et al., “The pharmacokinetics, pharmacodynamics and safety of oral doses of ilaprazole 10, 20 and 40 mg and esomeprazole 40 mg in healthy subjects: a randomised, open-label crossover study,” Alimentary Pharmacology & Therapeutics, vol. 40, no. 5, pp. 548–561, 2014. View at Publisher · View at Google Scholar · View at Scopus
  9. Y. Glupczynski, F. Megraud, M. Lopez-Brea, and L. P. Andersen, “European multicentre survey of in vitro antimicrobial resistance in Helicobacter pylori,” European Journal of Clinical Microbiology & Infectious Diseases, vol. 20, no. 11, pp. 820–823, 2001. View at Publisher · View at Google Scholar · View at Scopus
  10. P. Malfertheiner, F. Bazzoli, J. C. Delchier et al., “Helicobacter pylori eradication with a capsule containing bismuth subcitrate potassium, metronidazole, and tetracycline given with omeprazole versus clarithromycin-based triple therapy: a randomised, open-label, non-inferiority, phase 3 trial,” Lancet, vol. 377, no. 9769, pp. 905–913, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. J. W. Lee, N. Kim, J. M. Kim et al., “Prevalence of primary and secondary antimicrobial resistance of Helicobacter pylori in Korea from 2003 through 2012,” Helicobacter, vol. 18, no. 3, pp. 206–214, 2013. View at Publisher · View at Google Scholar · View at Scopus
  12. J. Y. Lee and N. Kim, “Future trends of Helicobacter pylori eradication therapy in Korea,” The Korean Journal of Gastroenterology, vol. 63, no. 3, p. 158, 2014. View at Google Scholar
  13. J. P. Gisbert and F. Morena, “Systematic review and meta-analysis: levofloxacin-based rescue regimens after Helicobacter pylori treatment failure,” Alimentary Pharmacology & Therapeutics, vol. 23, no. 1, pp. 35–44, 2006. View at Publisher · View at Google Scholar · View at Scopus
  14. S. P. Xiao, M. Gu, and G. X. Zhang, “Is levofloxacin-based triple therapy an alternative for first-line eradication of Helicobacter pylori? A systematic review and meta-analysis,” Scandinavian Journal of Gastroenterology, vol. 49, no. 5, pp. 528–538, 2014. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Castro-Fernandez, E. Lamas, A. Perez-Pastor et al., “Efficacy of triple therapy with a proton pump inhibitor, levofloxacin, and amoxicillin as first-line treatment to eradicate Helicobacter pylori,” Revista Española de Enfermedades Digestivas, vol. 101, no. 6, pp. 395–398, 2009. View at Google Scholar
  16. J. Molina-Infante, B. Perez-Gallardo, M. Fernandez-Bermejo et al., “Clinical trial: clarithromycin vs. levofloxacin in first-line triple and sequential regimens for Helicobacter pylori eradication,” Alimentary Pharmacology & Therapeutics, vol. 31, no. 10, pp. 1077–1084, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. D. Antos, W. Schneider-Brachert, E. Bastlein et al., “7-day triple therapy of Helicobacter pylori infection with levofloxacin, amoxicillin, and high-dose esomeprazole in patients with known antimicrobial sensitivity,” Helicobacter, vol. 11, no. 1, pp. 39–45, 2006. View at Publisher · View at Google Scholar · View at Scopus
  18. R. W. Schrauwen, M. J. Janssen, and W. A. de Boer, “Seven-day PPI-triple therapy with levofloxacin is very effective for Helicobacter pylori eradication,” The Netherlands Journal of Medicine, vol. 67, no. 3, pp. 96–101, 2009. View at Google Scholar
  19. E. J. Dickson and R. C. Stuart, “Genetics of response to proton pump inhibitor therapy: clinical implications,” American Journal of Pharmacogenomics, vol. 3, no. 5, pp. 303–315, 2003. View at Publisher · View at Google Scholar · View at Scopus
  20. J. Y. Lee, N. Kim, M. S. Kim et al., “Factors affecting first-line triple therapy of Helicobacter pylori including CYP2C19 genotype and antibiotic resistance,” Digestive Diseases and Sciences, vol. 59, no. 6, pp. 1235–1243, 2014. View at Publisher · View at Google Scholar · View at Scopus
  21. N. de Bortoli, I. Martinucci, M. Giacchino et al., “The pharmacokinetics of ilaprazole for gastro-esophageal reflux treatment,” Expert Opinion on Drug Metabolism & Toxicology, vol. 9, no. 10, pp. 1361–1369, 2013. View at Publisher · View at Google Scholar · View at Scopus
  22. L. Wang, L. Zhou, H. Hu, S. Lin, and J. Xia, “Ilaprazole for the treatment of duodenal ulcer: a randomized, double-blind and controlled phase III trial,” Current Medical Research and Opinion, vol. 28, no. 1, pp. 101–109, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. W. Wu, Y. Yang, and G. Sun, “Recent insights into antibiotic resistance in Helicobacter pylori eradication,” Gastroenterology Research and Practice, vol. 2012, Article ID 723183, p. 8, 2012. View at Publisher · View at Google Scholar · View at Scopus
  24. M. Abdullahi, B. Annibale, D. Capoccia et al., “The eradication of Helicobacter pylori is affected by body mass index (BMI),” Obesity Surgery, vol. 18, no. 11, pp. 1450–1454, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. J. Jiang, Y. Chen, J. Shi, C. Song, J. Zhang, and K. Wang, “Population attributable burden of Helicobacter pylori-related gastric cancer, coronary heart disease, and ischemic stroke in China,” European Journal of Clinical Microbiology & Infectious Diseases, vol. 36, no. 2, pp. 199–212, 2017. View at Publisher · View at Google Scholar
  26. W. S. Huang, C. H. Tseng, C. L. Lin, C. H. Tsai, and C. H. Kao, “Helicobacter pylori infection increases subsequent ischemic stroke risk: a nationwide population-based retrospective cohort study,” QJM, vol. 107, no. 12, pp. 969–975, 2014. View at Publisher · View at Google Scholar