Gastroenterology Research and Practice / 2017 / Article / Tab 3 / Clinical Study
Efficacy and Safety of the Triple Therapy Containing Ilaprazole, Levofloxacin, and Amoxicillin as First-Line Treatment in Helicobacter pylori Infections Table 3 Subgroup analysis of eradication rate.
Group (n ) Intention-to-treat analysis Per protocol analysis Eradication rate, n (%) Relative risk 95% CI valueEradication rate, n (%) Relative risk 95% CI valueTotal 75 (84.5) 71 (88.8) Age 0.947 1.000 <60 years old 43 (84.3) 1.035 0.370–2.894 43 (89.6) 1.024 0.870–1.205 ≥60 years old 28 (84.8) 0.994 0.825–1.197 28 (87.5) 0.833 0.242–2.869 Gender 0.650 1.000 Male 28 (82.4) 0.958 0.791–1.160 28 (87.5) 0.977 0.830–1.149 Female 43 (86.0) 1.261 0.464–3.425 43 (89.6) 1.200 0.349–4.132 BMI 0.064 0.032 Normal BMI 43 (91.5) 1.232 0.995–1.525 43 (95.6) 1.213 1.005–1.464 Overweight BMI 26 (74.3) 0.331 0.111–0.988 26 (78.8) 0.210 0.046–0.945 Alcohol 0.281 0.676 Drinker 17 (94.4) 3.279 0.455–23.522 16 (94.4) 2.323 0.311–17.361 Nondrinker 54 (81.8) 0.866 0.738–1.016 55 (87.1) 0.922 0.796–1.069 Smoking 1.000 1.000 Smoker 10 (90.9) 1.268 0.260–12.570 10 (90.9) 1.275 0.176–9.229 Nonsmoker 61 (83.6) 0.919 0.743–1.137 61 (88.4) 0.972 0.792–1.194 NSAIDs or antithrombotic agents 0.603 0.220 Yes 6 (75) 0.579 0.155–2.165 6 (75) 0.389 0.097–1.564 No 65 (85.5) 1.140 0.756–1.719 65 (90.3) 1.204 0.801–1.809 HTN 0.203 0.476 Yes 27 (93.1) 2.900 0.689–12.215 27 (93.1) 1.990 0.442–8.954 No 44 (80.0) 0.859 0.728–1.014 44 (86.3) 0.927 0.799–1.074 DM 1.000 1.000 Yes 7 (87.5) 1.263 0.188–8.492 7 (87.5) 0.889 0.127–6.225 No 64 (84.2) 0.962 0.728–1.273 64 (88.9) 1.016 0.772–1.337 CVA 0.063 0.033 Yes 1 (33.3) 0.206 0.078–0.544 1 (33.3) 0.138 0.048–0.402 No 69 (86.3) 2.588 0.521–12.851 69 (90.8) 2.724 0.549–13.516 Liver disease 1.000 0.523 Yes 5 (83.3) 0.923 0.143–5.950 5 (83.3) 0.649 0.097–4.359 No 66 (84.6) 1.015 0.701–1.470 66 (89.2) 1.070 0.742–1.544 PUD 1.000 1.000 Yes 18 (85.7) 1.019 0.830–1.251 18 (90) 1.019 0.857–1.211 No 53 (84.1) 0.900 0.273–2.964 53 (88.3) 0.857 0.194–3.795
CI: confidence interval; BMI: body mass index; NSAIDs: nonsteroidal anti-inflammatory drugs; HTN: hypertension; DM: diabetes mellitus; CVA: cerebrovascular accident; PUD: peptic ulcer disease. .