Efficacy and Safety of the Triple Therapy Containing Ilaprazole, Levofloxacin, and Amoxicillin as First-Line Treatment in Helicobacter pylori Infections

Table 3

Subgroup analysis of eradication rate.

Group (n)	Intention-to-treat analysis				Per protocol analysis
	Eradication rate,; n (%)	Relative risk	95% CI	value	Eradication rate,; n (%)	Relative risk	95% CI	value
Total	75 (84.5)				71 (88.8)
Age				0.947				1.000
<60 years old	43 (84.3)	1.035	0.370–2.894		43 (89.6)	1.024	0.870–1.205
≥60 years old	28 (84.8)	0.994	0.825–1.197		28 (87.5)	0.833	0.242–2.869
Gender				0.650				1.000
Male	28 (82.4)	0.958	0.791–1.160		28 (87.5)	0.977	0.830–1.149
Female	43 (86.0)	1.261	0.464–3.425		43 (89.6)	1.200	0.349–4.132
BMI				0.064				0.032
Normal BMI	43 (91.5)	1.232	0.995–1.525		43 (95.6)	1.213	1.005–1.464
Overweight BMI	26 (74.3)	0.331	0.111–0.988		26 (78.8)	0.210	0.046–0.945
Alcohol				0.281				0.676
Drinker	17 (94.4)	3.279	0.455–23.522		16 (94.4)	2.323	0.311–17.361
Nondrinker	54 (81.8)	0.866	0.738–1.016		55 (87.1)	0.922	0.796–1.069
Smoking				1.000				1.000
Smoker	10 (90.9)	1.268	0.260–12.570		10 (90.9)	1.275	0.176–9.229
Nonsmoker	61 (83.6)	0.919	0.743–1.137		61 (88.4)	0.972	0.792–1.194
NSAIDs or; antithrombotic; agents				0.603				0.220
Yes	6 (75)	0.579	0.155–2.165		6 (75)	0.389	0.097–1.564
No	65 (85.5)	1.140	0.756–1.719		65 (90.3)	1.204	0.801–1.809
HTN				0.203				0.476
Yes	27 (93.1)	2.900	0.689–12.215		27 (93.1)	1.990	0.442–8.954
No	44 (80.0)	0.859	0.728–1.014		44 (86.3)	0.927	0.799–1.074
DM				1.000				1.000
Yes	7 (87.5)	1.263	0.188–8.492		7 (87.5)	0.889	0.127–6.225
No	64 (84.2)	0.962	0.728–1.273		64 (88.9)	1.016	0.772–1.337
CVA				0.063				0.033
Yes	1 (33.3)	0.206	0.078–0.544		1 (33.3)	0.138	0.048–0.402
No	69 (86.3)	2.588	0.521–12.851		69 (90.8)	2.724	0.549–13.516
Liver disease				1.000				0.523
Yes	5 (83.3)	0.923	0.143–5.950		5 (83.3)	0.649	0.097–4.359
No	66 (84.6)	1.015	0.701–1.470		66 (89.2)	1.070	0.742–1.544
PUD				1.000				1.000
Yes	18 (85.7)	1.019	0.830–1.251		18 (90)	1.019	0.857–1.211
No	53 (84.1)	0.900	0.273–2.964		53 (88.3)	0.857	0.194–3.795

CI: confidence interval; BMI: body mass index; NSAIDs: nonsteroidal anti-inflammatory drugs; HTN: hypertension; DM: diabetes mellitus; CVA: cerebrovascular accident; PUD: peptic ulcer disease. .