Procalcitonin-Guided Antibiotics after Surgery for Peritonitis: A Randomized Controlled Study

Table 2

Baseline characteristics.

	Procalcitonin group; (n = 79)	Control group; (n = 83)	value
Median age (range), years	56 (36–73)	57 (36–71)	0.776
Males, n (%)	46 (58.2%)	47 (57%)	0.875
ASA 1-2, n (%)	46 (58.2%)	60 (72.3%)	0.07
ASA 3-4	33 (41.8%)	23 (27.7%)
Comorbidities, n (%)
(i) Diabetes mellitus	4 (5.1%)	4 (4.8%)	1.00
(ii) Pulmonary	13 (16.5%)	7 (8.4%)	0.15
(iii) Cardiac	29 (36.7%)	34 (41%)	0.63
(iv) Renal dysfunction	9 (11.4%)	8 (9.6%)	0.80
Needing ICU hospitalization, n (%)	10 (12.7%)	10 (12.0%)	1.00
Mannheim Peritonitis score (points)
(i) All	19 (11–25)	17 (12–26)	1.00
(ii) Subgroup 1	20 (16–26)	21 (15.5–27.5)
(iii) Subgroup 2	15 (10.8–21.3)	15 (10–21)
(iv) Subgroup 3	24.5 (17.8–29)	28 (21–38)
Peritonitis			0.91
(i) Trouble exsudat	5 (6.3%)	7 (8.4%)
(ii) Gastric/duodenal content	4 (5.1%)	5 (6.0%)
(iii) Fibrinous	3 (3.8%)	3 (3.6%)
(iv) Purulent	53 (67.1%)	52 (62.7%)
(v) Fecal	14 (17.7%)	16 (19.3%)
Peritonitis quadrants			0.73
1	33 (41.8%)	28 (33.7%)
2	10 (12.7%)	14 (16.7%)
3	3 (3.8%)	2 (2.4%)
4	33 (41.8%)	39 (47.0%)
Group 1 peritonitis due to GI perforation	31	33	0.95
(i) Diverticulitis	14	9
(ii) Perforated ulcer	4	11
(iii) Perforation stent/colonoscopy/biopsy	6	5
(iv) Ischemia–necrosis	6	2
(v) High-velocity trauma	0	2
(vi) Perforated tumor	1	1
(vii) Other	0	3
Group 2 peritonitis due to appendicitis	34	39	0.61
Group 3 postoperative peritonitis	14	11	0.43
(i) Anastomotic leakage	6	5

ASA: American Society of Anesthesiologists physical status classification system; ICU: intensive care unit.