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Gastroenterology Research and Practice
Volume 2017, Article ID 3526460, 5 pages
Research Article

Diagnostic Value of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Crohn’s Disease

1Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, China
2Hubei Clinical Center & Key Laboratory of Intestinal & Colorectal Diseases, Wuhan, China

Correspondence should be addressed to Qiu Zhao; moc.621@0909uiqoahz and Jin Li; moc.621@015432ilil

Received 27 March 2017; Revised 16 May 2017; Accepted 31 May 2017; Published 17 July 2017

Academic Editor: Andrew S. Day

Copyright © 2017 Jue-Rong Feng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The aim of this study is to investigate the diagnostic efficacy of neutrophil-to-lymphocyte ratio (NLR), neutrophil-to-monocyte ratio (NMR), lymphocyte-to-monocyte ratio (LMR), and platelet-to-lymphocyte ratio (PLR) in patients with Crohn’s disease (CD) and non-CD controls. These ratios were all derived from complete blood counts. Two hundred and six participants including CD inpatients and non-CD controls were retrospectively enrolled. We found statistically higher NLR and PLR and lower LMR in CD patients than in non-CD controls (all ). However, NMR was not different between the two groups (). In addition, NLR, PLR, and LMR were associated with CRP and ESR. Optimal cutoffs for NLR and PLR were 2.72 (sensitivity: 68.3%, specificity: 75.9%, and overall accuracy: 70.1%) and 132.88 (sensitivity: 76.7%, specificity: 84.8%, and overall accuracy: 80.8%), respectively. In conclusion, the NLR and PLR might be effective, readily available, and low-cost biomarkers for differentiating CD patients from non-CD controls.