The Methylation Status and Expression of Epstein-Barr Virus Early Genes BARF1 and BHRF1 in Epstein-Barr Virus-Associated Gastric Carcinomas

Table 2

The methylation ratio of CpG loci in BARF1p and BHRF1p before and after 5-aza treatment.

Cell line	Treatment	Methylation rate
		BARF1	BHRF1
B95-8	0 μmol/L 5-aza	46.7% (140/300)	32.7% (51/156)
	10 μmol/L 5-aza	0 (0/300)	0 (0/300)
GT39	0 μmol/L 5-aza	94.7% (284/300)	99.4% (155/156)
	10 μmol/L 5-aza	43.0% (129/300)	53.2% (83/156)
GT38	0 μmol/L 5-aza	95.3% (286/300)	97.4% (152/156)
	10 μmol/L 5-aza	75.0% (225/300)	52.6% (82/156)

The difference of methylation rate is significant ().