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Gastroenterology Research and Practice
Volume 2017 (2017), Article ID 3840243, 7 pages
https://doi.org/10.1155/2017/3840243
Research Article

Modulation of Colorectal Cancer Risk by Polymorphisms in 51Gln/His, 64Ile/Val, and 148Asp/Glu of APEX Gene; 23Gly/Ala of XPA Gene; and 689Ser/Arg of ERCC4 Gene

1Department of General and Colorectal Surgery, Medical University of Lodz, Lodz, Poland
2Department of Clinical Chemistry and Biochemistry, Medical University of Lodz, Lodz, Poland

Correspondence should be addressed to I. Majsterek; lp.zdol.demu@keretsjam.zsueneri

Received 21 September 2016; Revised 1 December 2016; Accepted 7 December 2016; Published 12 March 2017

Academic Editor: Nicola Silvestris

Copyright © 2017 L. Dziki et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Polymorphisms in DNA repair genes may affect the activity of the BER (base excision repair) and NER (nucleotide excision repair) systems. Using DNA isolated from blood taken from patients () and a control group () with CRC, we have analyzed the polymorphisms of selected DNA repair genes and we have demonstrated that genotypes 51Gln/His and 148Asp/Glu of APEX gene and 23Gly/Ala of XPA gene may increase the risk of colorectal cancer. At the same time analyzing the gene-gene interactions, we suggest the thesis that the main factor to be considered when analyzing the impact of polymorphisms on the risk of malignant transformation should be intergenic interactions. Moreover, we are suggesting that some polymorphisms may have impact not only on the malignant transformation but also on the stage of the tumor.