Modulation of Colorectal Cancer Risk by Polymorphisms in 51Gln/His, 64Ile/Val, and 148Asp/Glu of APEX Gene; 23Gly/Ala of XPA Gene; and 689Ser/Arg of ERCC4 Gene

Table 3

The distribution of genotypes and allele frequencies and the analysis of the odds ratio (OR) for 148Asp/Glu polymorphism of APEX gene in patients with colorectal cancer (CRC) and the control group.

Genotype/allele	Patients ()	Controls ()	OR (95% CI)
Asp/Asp	51	88	1 (ref)	—
Asp/Glu	237	158	2.588 (1.736–3.859)	<0.0001
Glu/Glu	21	55	0.659 (0.358–1.212)	0.179
Asp	339	334	1 (ref)	—
Glu	279	268	1.026 (0.819–1.285)	0.823

Genotype distribution in the Hardy-Weinberg equilibrium, χ² = 0.277.
Values set in italics denote statistical significance.