Association of Fucosyltransferase 2 Gene Polymorphisms with Inflammatory Bowel Disease in Patients from Southeast China
Table 2
FUT2 gene polymorphisms in patients with inflammatory bowel disease (IBD) and the controls.
FUT2
Controls
UC
CD
UC versus Controls
CD versus Controls
(%)
(%)
(%)
OR (95% CI)
OR (95% CI)
C357T
TT
379
292
217
1
1
TC (additive model)
112
91
57
1.055 (0.759–1.463)
0.742
0.889 (0.608–1.291)
0.521
CC (additive model)
11
13
1
1.534 (0.624–3.839)
0.302
0.159 (0.004–0.996)
0.045
Dominant model (TC+CC versus TT)
1.097 (0.811–1.485)
0.547
0.824 (0.578–1.173)
0.282
Recessive model (CC versus TT+TC)
1.515 (0.671–3.419)
0.314
0.824 (0.578–1.173)
0.282
Allele frequency model (C allele versus T allele)
1.125 (0.861–1.471)
0.387
0.780 (0.563–1.080)
0.134
A385T
AA
150
122
80
1
1
AT (additive model)
269
204
119
0.932 (0.691–1.259)
0.648
0.829 (0.586–1.1773)
0.290
TT (additive model)
83
70
76
1.037 (0.697–1.544)
0.858
1.717 (1.136–2.594)
0.010
Dominant model (AT+TT versus AA)
0.957 (0.719–1.274)
0.764
1.039 (0.752–1.435)
0.818
Recessive model (TT versus AA+AT)
1.084 (0.764–1.537)
0.651
0.519 (0.364–0.739)
0.000
Allele frequency model (T allele versus A allele)
1.004 (0.832–1.212)
0.964
1.271 (1.031–1.565)
0.024
G428A
GG
497
392
266
1
1
GA (additive model)
5
4
9
1.014 (0.271–3.802)
0.983
3.363 (1.116–10.137)
0.044
AA (additive model)
0
0
0
NA
NA
Dominant model (GA+AA versus GG)
1.014 (0.271–3.802)
0.983
3.363 (1.116–10.137)
0.044
Recessive model (AA versus GG+GA)
NA
NA
Allele frequency model (A allele versus G allele)
1.014 (0.271–3.789)
1.000
3.324 (1.108–9.968)
0.023
value, OR, and 95% CI were calculated by chi-squared test. Threshold of value is 0.05. values of statistical significance are in bold. NA, not calculated due to low frequencies. CI, confidence interval; OR, odds ratio. The first row of each comparison group was set as reference.
