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Gastroenterology Research and Practice
Volume 2017, Article ID 4164130, 9 pages
Research Article

Inflammatory Markers as Prognostic Factors of Survival in Patients Affected by Hepatocellular Carcinoma Undergoing Transarterial Chemoembolization

1Department of Radiology, University of Perugia, Perugia, Italy
2Department of General and Emergency Surgery, University of Perugia, Perugia, Italy
3Department of Medical Oncology, University of Perugia, Perugia, Italy
4Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy
5Department of Interventional Radiology, University La Sapienza, Rome, Italy

Correspondence should be addressed to E. Marino; moc.liamg@6891oniram.attebasile

Received 3 April 2017; Revised 13 June 2017; Accepted 6 July 2017; Published 15 August 2017

Academic Editor: Niccola Funel

Copyright © 2017 A. Rebonato et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Introduction. Transarterial chemoembolization (TACE) is a good choice for hepatocellular carcinoma (HCC) treatment when surgery and liver transplantation are not feasible. Few studies reported the value of prognostic factors influencing survival after chemoembolization. In this study, we evaluated whether preoperative inflammatory factors such as neutrophil to lymphocyte ratio and platelet to lymphocyte ratio affected our patient survival when affected by hepatocellular carcinoma. Methods. We retrospectively evaluated a total of 72 patients with hepatocellular carcinoma that underwent TACE. We enrolled patients with different etiopathogeneses of hepatitis and histologically proven HCC not suitable for surgery. The overall study population was dichotomized in two groups according to the median NLR value and was analyzed also according to other prognostic factors. Results. The global median overall survival (OS) was 28 months. The OS in patients with high NLR was statistically significantly shorter than that in patients with low NLR. The following pretreatment variables were significantly associated with the OS in univariate analyses: age, Child-Pugh score, BCLC stage, INR, and NLR. Pretreated high NLR was an independently unfavorable factor for OS. Conclusion. NLR could be considered a good prognostic factor of survival useful to stratify patients that could benefit from TACE treatment.