Research Article
Inflammatory Markers as Prognostic Factors of Survival in Patients Affected by Hepatocellular Carcinoma Undergoing Transarterial Chemoembolization
Table 1
Overall, high and low NLR subgroups patients’ characteristics and statistical differences between the two subgroups.
| | Mean (min-max) or frequencies
| Overall | Low NLR | High NLR | value |
| Sex (male/female) | 39/10 | 16/9 | 23/1 | 0.0106 | Age (years) | 75 (49–88)┼ | 75 (49–88)┼ | 74 (51–86)┼ | 0.477 | Etiology (HCV/Cripto/Alcol/others) | 18/19/10/2 | 11/9/3/2 | 7/10/7/0 | 0.2102 | Child-Pugh class (5/6/7/8/9) | 17/21/7/3/1 | 8/10/5/1/1 | 9/11/2/2/0 | 0.6081 | Neutrophil (/mm3) | 3485 (811–9130)┼ | 2389 (811–6019)┼ | 4533 (1920–9130)┼ | 0.002 | Lymphocyte (/mm3) | 1321 (360–2970)┼ | 1553 (759–2970)┼ | 1110 (360–1977)┼ | 0.0107 | Neutrophil/lymphocyte | 3.25 (0.61–19.02)┼ Median 2.03 | 1.5 (0.61–2.03)┼ | 5.06 (2.19–19.02)┼ | 0.0004 | Platelet (/mm3) | 115.857 (51.000–243.000)┼ | 111.041 (51.000–243.000)┼ | 117.000 (53.000–188.000)┼ | 0.6607 | Platelet/lymphocyte | 99 (33–391)┼ | 75.43 (33.69–142.83)┼ | 124.40 (52.50–391.78)┼ | 0.0048 | BCLC stage (B/C) | 34/15 | 17/8 | 17/7 | 0.9244 | Tumor size (<5/>5 cm) | 23/26 | 13/11 | 10/15 | 0.4796 | Number of tumors (<3/3–5/>5) | 25/9/15 | 15/4/6 | 10/5/9 | 0.4293 | Extrahepatic spread (absent/present) | 49/0 | 25/0 | 24/0 | 1.0 | Bilobar spread (absent/present) | 18/31 | 12/13 | 6/18 | 0.1697 | Ascites (absent/present) | 37/12 | 20/5 | 17/7 | 0.6791 | Albumin (g/dL) | 3.70 (2.51–4.80)┼ | 3.55 (2.51–4.46)┼ | 3.83 (2.77–4.80)┼ | 0.7460 | Bilirubin (mg/dL) | 1.04 (0.08–3.07)┼ | 0.96 (0.08–2.42)┼ | 1.11 (0.32–3.07)┼ | 0.6570 | INR | 1.18 (0.92–1.68)┼ | 1.20 (0.92–1.68)┼ | 1.16 (1.00–1.40)┼ | 0.1409 | Creatinine (mg/dL) | 0.90 (0.45–2.28)┼ | 0.84 (0.45–1.80)┼ | 0.95 (0.57–2.28)┼ | 0.2198 | GFR (mL/min) | 96.56 (29.00–197.00)┼ | 100.09 (29.00–197.00)┼ | 93.63 (30.00–146.00)┼ | 0.4283 |
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Fisher’s exact test; χ2-test; Student’s t-test; ┼min-max; BCLC = Barcelona Clinic Liver Cancer; Cripto = criptogenetic; GFR = glomerular filtration rate; HCV = hepatitis C virus; INR = International Normalized Ratio; NLR = neutrophil to lymphocyte ratio; PLR = platelet to lymphocyte ratio.
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