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Gastroenterology Research and Practice
Volume 2017 (2017), Article ID 4532320, 7 pages
https://doi.org/10.1155/2017/4532320
Research Article

Impact of Fatty Liver on Acute Pancreatitis Severity

1Division of Gastroenterology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
2Cancer Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
3Department of Radiology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
4Center for Cancer Prevention and Detection, National Cancer Center, Goyang-si, Republic of Korea

Correspondence should be addressed to In Seok Lee; rk.ca.cilohtac@elsi

Received 24 December 2016; Accepted 22 March 2017; Published 27 April 2017

Academic Editor: Alessandro Zerbi

Copyright © 2017 Seung Bae Yoon et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Aim. Acute pancreatitis is typically a mild disease, but some patients develop severe courses. Fatty liver changes are seen in patients with acute pancreatitis, but its clinical significance has not been well-studied. We aimed to investigate the relationship between fatty liver and the severity of acute pancreatitis. Methods. Unenhanced CT images of patients with acute pancreatitis were retrospectively reviewed by a radiologist, and mean hepatic and splenic attenuation was measured in Hounsfield units (HU). Fatty liver was defined as mean hepatic/splenic . Results. Among 200 patients, fatty liver was found in 67 (33.5%) and nonfatty liver in 133 (66.5%). Compared with patients without fatty liver, the severity of pancreatitis and levels of serum C-reactive protein were higher in fatty liver patients. The prevalence of local complications, persistent organ failure, and mortality were also higher in patients with fatty liver. Even after adjusting for age, sex, body mass index, and cause of pancreatitis, fatty liver was significantly associated with moderately severe or severe acute pancreatitis. Conclusions. Fatty liver may play a prognostic role in acute pancreatitis. Fatty liver could be incorporated into future predictive scoring models.