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Gastroenterology Research and Practice
Volume 2017, Article ID 4596176, 10 pages
Clinical Study

Impact of Pressurized Intraperitoneal Aerosol Chemotherapy on Quality of Life and Symptoms in Patients with Peritoneal Carcinomatosis: A Retrospective Cohort Study

1Department of Visceral Surgery, University Hospital of Lausanne (CHUV), Lausanne, Switzerland
2Department of Gynecology, University Hospital of Lausanne (CHUV), Lausanne, Switzerland
3Department of Digestive Surgery, Strasbourg University, Strasbourg, France
4Department of Oncology, University Hospital of Lausanne (CHUV), Lausanne, Switzerland

Correspondence should be addressed to Nicolas Demartines; hc.vuhc@senitramed

Received 15 September 2016; Accepted 18 December 2016; Published 21 February 2017

Academic Editor: Guoxiang Cai

Copyright © 2017 Hugo Teixeira Farinha et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Peritoneal cancer treatment aims to prolong survival, but preserving Quality of Life (QoL) under treatment is also a priority. Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) is a novel minimally invasive repeatable treatment modality. The aim of the present study was to assess QoL in our cohort of PIPAC patients. Methods. Analysis of all consecutive patients included from the start of PIPAC program (January 2015). QoL (0–100: optimal) and symptoms (no symptom: 0–100) were measured prospectively before and after every PIPAC procedure using EORTC QLQ-C30. Results. Forty-two patients (M : F = 8 : 34, median age 66 (59–73) years) had 91 PIPAC procedures in total (1 : 4x, 17 : 3x, 12 : 2x, and 12 : 1x). Before first PIPAC, baseline QoL was measured as median of . Prominent complaints were fatigue () and digestive symptoms as diarrhea (), constipation (), and nausea (). Overall Quality of Life was after PIPAC#1 (), after PIPAC#2 (), and after PIPAC#3 (). Fatigue symptom score was after PIPAC#1 and and after second and third applications, respectively (). Diarrhea (), constipation (), and nausea () did not change significantly under PIPAC treatment. Conclusion. PIPAC treatment of peritoneal carcinomatosis had no negative impact on patients’ overall QoL and its components or on main symptoms. This study was registered online on Research Registry (UIN: 1608).