Table of Contents Author Guidelines Submit a Manuscript
Gastroenterology Research and Practice
Volume 2017, Article ID 5023680, 9 pages
https://doi.org/10.1155/2017/5023680
Research Article

T Helper Lymphocyte and Mast Cell Immunohistochemical Pattern in Nonceliac Gluten Sensitivity

1Section of Gastroenterology, Department of Emergency and Organ Transplantation, University “Aldo Moro”, Bari, Italy
2Section of Pathology, Department of Emergency and Organ Transplantation, University “Aldo Moro”, Bari, Italy

Correspondence should be addressed to Giuseppe Losurdo; ti.ecila@soleppesuig

Received 26 August 2017; Accepted 29 October 2017; Published 7 December 2017

Academic Editor: Fabiana Zingone

Copyright © 2017 Giuseppe Losurdo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Fasano, A. Sapone, V. Zevallo, and D. Schuppan, “Nonceliac gluten sensitivity,” Gastroenterology, vol. 148, no. 6, pp. 1195–1204, 2015. View at Publisher · View at Google Scholar · View at Scopus
  2. A. Carroccio, P. Mansueto, G. Iacono et al., “Non-celiac wheat sensitivity diagnosed by double-blind placebo-controlled challenge: exploring anew clinical entity,” The American Journal of Gastroenterology, vol. 107, no. 12, pp. 1898–1906, 2012. View at Publisher · View at Google Scholar · View at Scopus
  3. U. Volta and R. De Giorgio, “New understanding of gluten sensitivity,” Nature Reviews Gastroenterology & Hepatology, vol. 9, no. 5, pp. 295–299, 2012. View at Publisher · View at Google Scholar · View at Scopus
  4. G. Caio, G. Riegler, M. Patturelli, A. Facchiano, L. De Magistris, and A. Sapone, “Pathophysiology of non-celiac gluten sensitivity: where are we now?” Minerva Gastroenterologica e Dietologica, vol. 63, no. 1, pp. 16–21, 2017. View at Publisher · View at Google Scholar
  5. A. Sapone, K. M. Lammers, V. Casolaro et al., “Divergence of gut permeability and mucosal immune gene expression in two gluten-associated conditions: celiac disease and gluten sensitivity,” BMC Medicine, vol. 9, p. 23, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. U. Volta, F. Tovoli, R. Cicola et al., “Serological tests in gluten sensitivity (non celiac gluten intolerance),” Journal of Clinical Gastroenterology, vol. 46, no. 8, pp. 680–685, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. C. Catassi, J. C. Bai, B. Bonaz et al., “Non-celiac gluten sensitivity: the new frontier of gluten related disorders,” Nutrients, vol. 5, no. 10, pp. 3839–3853, 2013. View at Publisher · View at Google Scholar · View at Scopus
  8. R. Francavilla, F. Cristofori, S. Castellaneta et al., “Clinical, serologic, and histologic features of gluten sensitivity in children,” Journal of Pediatrics, vol. 164, no. 3, pp. 463–467.e1, 2014. View at Publisher · View at Google Scholar · View at Scopus
  9. G. Losurdo, D. Piscitelli, A. Giangaspero et al., “Evolution of nonspecific duodenal lymphocytosis over 2 years of follow-up,” World Journal of Gastroenterology, vol. 21, no. 24, pp. 7545–7552, 2015. View at Publisher · View at Google Scholar · View at Scopus
  10. K. Rostami, D. Aldulaimi, G. Holmes et al., “Microscopic enteritis: Bucharest consensus,” World Journal of Gastroenterology, vol. 21, no. 9, pp. 2593–2604, 2015. View at Publisher · View at Google Scholar · View at Scopus
  11. E. Ierardi, G. Losurdo, A. Iannone et al., “Lymphocytic duodenitis or microscopic enteritis and gluten-related conditions: what needs to be explored?” Annals of Gastroenterology, vol. 30, no. 4, pp. 380–392, 2017. View at Publisher · View at Google Scholar
  12. V. Villanacci, A. Lanzini, F. Lanzarotto, and C. Ricci, “Observations on the paper of Carroccio et al. “non-celiac wheat sensitivity diagnosed by double-blind placebo-controlled challenge: exploring a new clinical entity”,” The American Journal of Gastroenterology, vol. 108, no. 4, pp. 619-620, 2013. View at Publisher · View at Google Scholar · View at Scopus
  13. C. Catassi, L. Elli, B. Bonaz et al., “Diagnosis of non-celiac gluten sensitivity (NCGS): the Salerno experts’ criteria,” Nutrients, vol. 7, no. 6, pp. 4966–4977, 2015. View at Publisher · View at Google Scholar · View at Scopus
  14. J. F. Ludvigsson, J. C. Bai, F. Biagi et al. British Society of Gastroenterology, “Diagnosis and management of adult coeliac disease: guidelines from the British Society of Gastroenterology,” Gut, vol. 63, no. 8, pp. 1210–1228, 2014. View at Publisher · View at Google Scholar · View at Scopus
  15. H. M. Moore, A. B. Kelly, S. D. Jewell et al., “Biospecimen reporting for improved study quality (BRISQ),” Cancer Cytopathology, vol. 119, no. 2, pp. 92–102, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. A. Tosco, M. Maglio, F. Paparo, L. Greco, R. Troncone, and R. Auricchio, “Discriminant score for celiac disease based on immunohistochemical analysis of duodenal biopsies,” Journal of Pediatric Gastroenterology and Nutrition, vol. 60, no. 5, pp. 621–5, 2015. View at Publisher · View at Google Scholar · View at Scopus
  17. A. Di Sabatino, P. Giuffrida, G. Fornasa et al., “Innate and adaptive immunity in self-reported nonceliac gluten sensitivity versus celiac disease,” Digestive and Liver Disease, vol. 48, no. 7, pp. 745–752, 2016. View at Publisher · View at Google Scholar · View at Scopus
  18. M. Brottveit, A. C. Beitnes, S. Tollefsen et al., “Mucosal cytokine response after short-term gluten challenge in celiac disease and non-celiac gluten sensitivity,” The American Journal of Gastroenterology, vol. 108, no. 5, pp. 842–850, 2013. View at Publisher · View at Google Scholar · View at Scopus
  19. C. Bucci, F. Zingone, I. Russo et al., “Gliadin does not induce mucosal inflammation or basophil activation in patients with nonceliac gluten sensitivity,” Clinical Gastroenterology and Hepatology, vol. 11, no. 10, pp. 1294–1299.e1, 2013. View at Publisher · View at Google Scholar · View at Scopus
  20. M. Uhde, M. Ajamian, G. Caio et al., “Intestinal cell damage and systemic immune activation in individuals reporting sensitivity to wheat in the absence of coeliac disease,” Gut, vol. 65, no. 12, pp. 1930–1937, 2016. View at Publisher · View at Google Scholar · View at Scopus
  21. J. Hollon, E. L. Puppa, B. Greenwald, E. Goldberg, A. Guerrerio, and A. Fasano, “Effect of gliadin on permeability of intestinal biopsy explants from celiac disease patients and patients with non-celiac gluten sensitivity,” Nutrients, vol. 7, no. 3, pp. 1565–1576, 2015. View at Publisher · View at Google Scholar · View at Scopus
  22. M. Mino and G. Y. Lauwers, “Role of lymphocytic immunophenotyping in the diagnosis of gluten-sensitive enteropathy with preserved villous architecture,” The American Journal of Surgical Pathology, vol. 27, no. 9, pp. 1237–1242, 2003. View at Publisher · View at Google Scholar · View at Scopus
  23. F. Biagi, O. Luinetti, J. Campanella et al., “Intraepithelial lymphocytes in the villous tip: do they indicate potential coeliac disease?” Journal of Clinical Pathology, vol. 57, no. 8, pp. 835–839, 2004. View at Publisher · View at Google Scholar · View at Scopus
  24. D. Branski, A. Fasano, and R. Troncone, “Latest developments in the pathogenesis and treatment of celiac disease,” The Journal of Pediatrics, vol. 149, no. 3, pp. 295–300, 2006. View at Publisher · View at Google Scholar · View at Scopus
  25. R. E. Araya, M. F. Gomez Castro, P. Carasi et al., “Mechanisms of innate immune activation by gluten peptide p31-43 in mice,” American Journal of Physiology. Gastrointestinal and Liver Physiology, vol. 311, no. 1, pp. G40–G49, 2016. View at Publisher · View at Google Scholar · View at Scopus
  26. G. Losurdo, F. Giorgio, D. Piscitelli et al., “May the assessment of baseline mucosal molecular pattern predict the development of gluten related disorders among microscopic enteritis?” World Journal of Gastroenterology, vol. 22, no. 35, pp. 8017–8025, 2016. View at Publisher · View at Google Scholar · View at Scopus
  27. L. Palová-Jelínková, K. Dáňová, H. Drašarová et al., “Pepsin digest of wheat gliadin fraction increases production of IL-1β via TLR4/MyD88/TRIF/MAPK/NF-κB signaling pathway and an NLRP3 inflammasome activation,” PLoS One, vol. 8, no. 4, article e62426, 2013. View at Publisher · View at Google Scholar · View at Scopus
  28. V. F. Zevallos, V. Raker, S. Tenzer et al., “Nutritional wheat amylase-trypsin inhibitors promote intestinal inflammation via activation of myeloid cells,” Gastroenterology, vol. 152, no. 5, pp. 1100–1113.e12, 2017. View at Publisher · View at Google Scholar
  29. Y. Junker, S. Zeissig, S. J. Kim et al., “Wheat amylase trypsin inhibitors drive intestinal inflammation via activation of toll-like receptor 4,” The Journal of Experimental Medicine, vol. 209, no. 13, pp. 2395–2408, 2012. View at Publisher · View at Google Scholar · View at Scopus
  30. D. Schuppan and V. Zevallos, “Wheat amylase trypsin inhibitors as nutritional activators of innate immunity,” Digestive Diseases, vol. 33, no. 2, pp. 260–263, 2015. View at Publisher · View at Google Scholar · View at Scopus
  31. B. Frossi, C. Tripodo, C. Guarnotta et al., “Mast cells are associated with the onset and progression of celiac disease,” Journal of Allergy and Clinical Immunology, vol. 139, no. 4, pp. 1266–1274.e1, 2017. View at Publisher · View at Google Scholar · View at Scopus
  32. S. Merluzzi, B. Frossi, G. Gri, S. Parusso, C. Tripodo, and C. Pucillo, “Mast cells enhance proliferation of B lymphocytes and drive their differentiation toward IgA-secreting plasma cells,” Blood, vol. 115, no. 14, pp. 2810–2817, 2010. View at Publisher · View at Google Scholar · View at Scopus
  33. A. Carroccio, P. Mansueto, A. D'Alcamo, and G. Iacono, “Non-celiac wheat sensitivity as an allergic condition: personal experience and narrative review,” The American Journal of Gastroenterology, vol. 108, no. 12, pp. 1845–1852, 2013. View at Publisher · View at Google Scholar · View at Scopus