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Gastroenterology Research and Practice
Volume 2017, Article ID 5135172, 10 pages
https://doi.org/10.1155/2017/5135172
Review Article

Genetic Polymorphisms: A Novel Perspective on Acute Pancreatitis

1Sichuan Key Laboratory of Medical Imaging and Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China
2Sichuan Key Laboratory of Medical Imaging and Department of Pathophysiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China
3Biology Group, North Sichuan Medical College, Nanchong, China
4Sichuan Key Laboratory of Medical Imaging, North Sichuan Medical College, Nanchong, China
5Radiology Department, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China

Correspondence should be addressed to Xiao Ming Zhang; moc.361.piv@mxhz.rjc

Received 13 May 2017; Accepted 10 August 2017; Published 3 December 2017

Academic Editor: Piero Chirletti

Copyright © 2017 Yong Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Acute pancreatitis (AP) is a complex disease that results in significant morbidity and mortality. For many decades, it has compelled researchers to explore the exact pathogenesis and the understanding of the pathogenesis of AP has progressed dramatically. Currently, premature trypsinogen activation and NF-κB activation for inflammation are two remarkable hypotheses for the mechanism of AP. Meanwhile, understanding of the influence of genetic polymorphisms has resulted in tremendous development in the understanding of the advancement of complex diseases. Now, genetic polymorphisms of AP have been noted gradually and many researchers devote themselves to this emerging area. In this review, we comprehensively describe genetic polymorphisms combined with the latest hypothesis of pathogenesis associated with AP.