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Gastroenterology Research and Practice
Volume 2017, Article ID 5135172, 10 pages
https://doi.org/10.1155/2017/5135172
Review Article

Genetic Polymorphisms: A Novel Perspective on Acute Pancreatitis

1Sichuan Key Laboratory of Medical Imaging and Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China
2Sichuan Key Laboratory of Medical Imaging and Department of Pathophysiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China
3Biology Group, North Sichuan Medical College, Nanchong, China
4Sichuan Key Laboratory of Medical Imaging, North Sichuan Medical College, Nanchong, China
5Radiology Department, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China

Correspondence should be addressed to Xiao Ming Zhang; moc.361.piv@mxhz.rjc

Received 13 May 2017; Accepted 10 August 2017; Published 3 December 2017

Academic Editor: Piero Chirletti

Copyright © 2017 Yong Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. Yadav and A. B. Lowenfels, “The epidemiology of pancreatitis and pancreatic cancer,” Gastroenterology, vol. 144, no. 6, pp. 1252–1261, 2013. View at Publisher · View at Google Scholar · View at Scopus
  2. F. ChE, S. S. Vege, and C. M. Wilcox, “Acute pancreatitis,” New England Journal of Medicine, vol. 376, no. 6, pp. 596–599, 2017. View at Publisher · View at Google Scholar
  3. J. L. Frossard, M. L. Steer, and C. M. Pastor, “Acute pancreatitis,” The Lancet, vol. 371, no. 9607, pp. 143–152, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. D. C. Whitcomb, “Genetic risk factors for pancreatic disorders,” Gastroenterology, vol. 144, no. 6, pp. 1292–1302, 2013. View at Publisher · View at Google Scholar · View at Scopus
  5. A. K. Saluja, M. M. Lerch, P. A. Phillips, and V. Dudeja, “Why does pancreatic overstimulation cause pancreatitis,” Annual Review of Physiology, vol. 69, no. 1, pp. 249–269, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. F. S. Gorelick and E. Thrower, “The acinar cell and early pancreatitis responses,” Clinical Gastroenterology and Hepatology, vol. 7, no. 11, pp. S10–S14, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. R. P. Sah, R. K. Dawra, and A. K. Saluja, “New insights into the pathogenesis of pancreatitis,” Current Opinion in Gastroenterology, vol. 29, no. 5, pp. 523–530, 2013. View at Publisher · View at Google Scholar · View at Scopus
  8. R. P. Sah and A. Saluja, “Molecular mechanisms of pancreatic injury,” Current Opinion in Gastroenterology, vol. 27, no. 5, pp. 444–451, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. Z. Kukor, M. Tóth, and M. Sahin-Tóth, “Human anionic trypsinogen: properties of autocatalytic activation and degradation and implications in pancreatic diseases,” European Journal of Biochemistry, vol. 270, no. 9, pp. 2047–2058, 2003. View at Publisher · View at Google Scholar · View at Scopus
  10. P. Hegyi, “Blockade of calcium entry provides a therapeutic window in acute pancreatitis,” The Journal of Physiology, vol. 594, no. 2, p. 257, 2016. View at Publisher · View at Google Scholar · View at Scopus
  11. P. Hegyi and O. H. Petersen, “The exocrine pancreas: the acinar-ductal tango in physiology and pathophysiology,” Reviews of Physiology, Biochemistry and Pharmacology, vol. 165, pp. 1–30, 2013. View at Publisher · View at Google Scholar · View at Scopus
  12. O. A. Mareninova, K. Hermann, S. W. French et al., “Impaired autophagic flux mediates acinar cell vacuole formation and trypsinogen activation in rodent models of acute pancreatitis,” Journal of Clinical Investigation, vol. 119, no. 11, pp. 3340–3355, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. S. J. Pandol, A. K. Saluja, C. W. Imrie, and P. A. Banks, “Acute pancreatitis: bench to the bedside,” Gastroenterology, vol. 132, no. 3, pp. 1127–1151, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. S. Beer, J. Zhou, A. Szabó et al., “Comprehensive functional analysis of chymotrypsin C (CTRC) variants reveals distinct loss-of-function mechanisms associated with pancreatitis risk,” Gut, vol. 62, no. 11, pp. 1616–1624, 2013. View at Publisher · View at Google Scholar · View at Scopus
  15. A. Szabó and M. Sahin-Tóth, “Determinants of chymotrypsin C cleavage specificity in the calcium-binding loop of human cationic trypsinogen,” FEBS Journal, vol. 279, no. 23, pp. 4283–4292, 2012. View at Publisher · View at Google Scholar · View at Scopus
  16. A. Khalid, S. Finkelstein, B. Thompson et al., “A 93 year old man with the PRSS1 R122H mutation, low SPINK1 expression, and no pancreatitis: insights into phenotypic non-penetrance,” Gut, vol. 55, no. 5, pp. 728–731, 2006. View at Publisher · View at Google Scholar · View at Scopus
  17. T. Athwal, W. Huang, R. Mukherjee et al., “Expression of human cationic trypsinogen (PRSS1) in murine acinar cells promotes pancreatitis and apoptotic cell death,” Cell Death and Disease, vol. 5, no. 4, article e1165, 2014. View at Publisher · View at Google Scholar · View at Scopus
  18. D. C. Whitcomb, J. LaRusch, A. M. Krasinskas et al., “Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis,” Nature Genetics, vol. 44, no. 12, pp. 1349–1354, 2012. View at Publisher · View at Google Scholar · View at Scopus
  19. A. V. Polonikov, T. A. Samgina, P. M. Nazarenko, O. Y. Bushueva, and V. P. Ivanov, “Alcohol consumption and cigarette smoking are important modifiers of the association between acute pancreatitis and the PRSS1-PRSS2 locus in men,” Pancreas, vol. 46, no. 2, pp. 230–236, 2017. View at Publisher · View at Google Scholar · View at Scopus
  20. B. C. Németh and M. Sahin-Tóth, “Human cationic trypsinogen (PRSS1) variants and chronic pancreatitis,” American Journal of Physiology Gastrointestinal and Liver Physiology, vol. 306, no. 6, pp. G466–G473, 2014. View at Publisher · View at Google Scholar · View at Scopus
  21. M. H. Derikx, P. Kovacs, M. Scholz et al., “Polymorphisms at PRSS1-PRSS2 and CLDN2-MORC4 loci associate with alcoholic and non-alcoholic chronic pancreatitis in a European replication study,” Gut, vol. 64, no. 9, pp. 1426–1433, 2015. View at Publisher · View at Google Scholar · View at Scopus
  22. P. K. Garg, R. Khajuria, M. Kabra, and S. S. Shastri, “Association of SPINK1 gene mutation and CFTR gene polymorphisms in patients with pancreas divisum presenting with idiopathic pancreatitis,” Journal of Clinical Gastroenterology, vol. 43, no. 9, pp. 848–852, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. E. Aoun, V. Muddana, G. I. Papachristou, and D. C. Whitcomb, “SPINK1 N34S is strongly associated with recurrent acute pancreatitis but is not a risk factor for the first or sentinel acute pancreatitis event,” The American Journal of Gastroenterology, vol. 105, no. 2, pp. 446–451, 2010. View at Publisher · View at Google Scholar · View at Scopus
  24. M. Pelaez-Luna, G. Robles-Diaz, S. Canizales-Quinteros, and M. T. Tusié-Luna, “PRSS1 and SPINK1 mutations in idiopathic chronic and recurrent acute pancreatitis,” World Journal of Gastroenterology, vol. 20, no. 33, pp. 11788–11792, 2014. View at Publisher · View at Google Scholar · View at Scopus
  25. E. Tukiainen, M. L. Kylänpää, E. Kemppainen et al., “Pancreatic secretory trypsin inhibitor (SPINK1) gene mutations in patients with acute pancreatitis,” Pancreas, vol. 30, no. 3, pp. 239–242, 2005. View at Publisher · View at Google Scholar · View at Scopus
  26. P. Rai, A. Sharma, A. Gupta, and R. Aggarwal, “Frequency of SPINK1 N34S mutation in acute and recurrent acute pancreatitis,” Journal of Hepato-Biliary-Pancreatic Sciences, vol. 21, no. 9, pp. 663–668, 2014. View at Publisher · View at Google Scholar · View at Scopus
  27. D. Koziel, S. Gluszek, A. Kowalik, M. Chlopek, and L. Pieciak, “Genetic mutations in SPINK1, CFTR, CTRC genes in acute pancreatitis,” BMC Gastroenterology, vol. 15, no. 1, p. 70, 2015. View at Publisher · View at Google Scholar · View at Scopus
  28. S. Midha, R. Khajuria, S. Shastri, M. Kabra, and P. K. Garg, “Idiopathic chronic pancreatitis in India: phenotypic characterisation and strong genetic susceptibility due to SPINK1 and CFTR gene mutations,” Gut, vol. 59, no. 6, pp. 800–807, 2010. View at Publisher · View at Google Scholar · View at Scopus
  29. K. Räsänen, O. Itkonen, H. Koistinen, and U. H. Stenman, “Emerging roles of SPINK1 in cancer,” Clinical Chemistry, vol. 62, no. 3, pp. 449–457, 2016. View at Publisher · View at Google Scholar · View at Scopus
  30. J. Rosendahl, H. Witt, R. Szmola et al., “Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis,” Nature Genetics, vol. 40, no. 1, pp. 78–82, 2008. View at Publisher · View at Google Scholar · View at Scopus
  31. S. Paliwal, S. Bhaskar, K. R. Mani et al., “Comprehensive screening of chymotrypsin C (CTRC) gene in tropical calcific pancreatitis identifies novel variants,” Gut, vol. 62, no. 11, pp. 1602–1606, 2013. View at Publisher · View at Google Scholar · View at Scopus
  32. D. Koziel, S. Gluszek, A. Kowalik, and M. Chlopek, “CTRC gene polymorphism (p.G60=; c.180 C > T) in acute pancreatitis,” BMC Gastroenterology, vol. 17, no. 1, p. 13, 2017. View at Publisher · View at Google Scholar
  33. P. Singh and P. K. Garg, “Pathophysiological mechanisms in acute pancreatitis: current understanding,” Indian Journal of Gastroenterology, vol. 35, no. 3, pp. 153–166, 2016. View at Publisher · View at Google Scholar · View at Scopus
  34. A. M. Smithies, K. Sargen, A. G. Demaine, and A. N. Kingsnorth, “Investigation of the interleukin 1 gene cluster and its association with acute pancreatitis,” Pancreas, vol. 20, no. 3, pp. 234–240, 2000. View at Publisher · View at Google Scholar · View at Scopus
  35. J. J. Powell, K. C. Fearon, A. K. Siriwardena, and J. A. Ross, “Evidence against a role for polymorphisms at tumor necrosis factor, interleukin-1 and interleukin-1 receptor antagonist gene loci in the regulation of disease severity in acute pancreatitis,” Surgery, vol. 129, no. 5, pp. 633–640, 2001. View at Publisher · View at Google Scholar · View at Scopus
  36. Y. W. Yin, Q. Q. Sun, J. Q. Feng, A. M. Hu, H. L. Liu, and Q. Wang, “Influence of interleukin gene polymorphisms on development of acute pancreatitis: a systematic review and meta-analysis,” Molecular Biology Reports, vol. 40, no. 10, pp. 5931–5941, 2013. View at Publisher · View at Google Scholar · View at Scopus
  37. F. Cai, N. Cui, H. Ma, X. Wang, G. Qiao, and D. Liu, “Interleukin-10-1082A/G polymorphism is associated with the development of acute pancreatitis in a Chinese population,” International Journal of Clinical and Experimental Pathology, vol. 8, no. 11, pp. 15170–15176, 2015. View at Google Scholar
  38. S. H. Rahman, K. Ibrahim, M. Larvin, A. Kingsnorth, and M. J. McMahon, “Association of antioxidant enzyme gene polymorphisms and glutathione status with severe acute pancreatitis,” Gastroenterology, vol. 126, no. 5, pp. 1312–1322, 2004. View at Publisher · View at Google Scholar · View at Scopus
  39. F. D’Oliveira Martins, B. C. Gomes, A. S. Rodrigues, and J. Rueff, “Genetic susceptibility in acute pancreatitis: genotyping of GSTM1, GSTT1, GSTP1, CASP7, CASP8, CASP9, CASP10, LTA, TNFRSF1B, and TP53 gene variants,” Pancreas, vol. 46, no. 1, pp. 71–76, 2017. View at Publisher · View at Google Scholar
  40. S. P. Ip, P. C. Kwan, C. H. Williams, S. Pang, N. M. Hooper, and P. S. Leung, “Changes of angiotensin-converting enzyme activity in the pancreas of chronic hypoxia and acute pancreatitis,” The International Journal of Biochemistry & Cell Biology, vol. 35, no. 6, pp. 944–954, 2003. View at Publisher · View at Google Scholar · View at Scopus
  41. F. Fang, J. Pan, L. Xu, G. Su, G. Li, and J. Wang, “Association between angiotensin-converting enzyme gene insertion/deletion polymorphism and pancreatitis risk: a meta-analysis,” Journal of the Renin-Angiotensin-Aldosterone System, vol. 16, no. 4, pp. 820–826, 2015. View at Publisher · View at Google Scholar · View at Scopus
  42. J. R. Skipworth, R. M. Nijmeijer, H. C. van Santvoort et al., “The effect of renin angiotensin system genetic variants in acute pancreatitis,” Annals of Surgery, vol. 261, no. 1, pp. 180–188, 2015. View at Publisher · View at Google Scholar · View at Scopus
  43. Y. Sakai, A. Masamune, A. Satoh, J. Nishihira, T. Yamagiwa, and T. Shimosegawa, “Macrophage migration inhibitory factor is a critical mediator of severe acute pancreatitis,” Gastroenterology, vol. 124, no. 3, pp. 725–736, 2003. View at Publisher · View at Google Scholar · View at Scopus
  44. S. H. Rahman, K. V. Menon, J. H. Holmfield, M. J. McMahon, and J. P. Guillou, “Serum macrophage migration inhibitory factor is an early marker of pancreatic necrosis in acute pancreatitis,” Annals of Surgery, vol. 245, no. 2, pp. 282–289, 2007. View at Publisher · View at Google Scholar · View at Scopus
  45. R. Makhija, A. Kingsnorth, and A. Demaine, “Gene polymorphisms of the macrophage migration inhibitory factor and acute pancreatitis,” Journal of the Pancreas, vol. 8, no. 3, pp. 289–295, 2007. View at Google Scholar
  46. W. K. Alderton, C. E. Cooper, and R. G. Knowles, “Nitric oxide synthases: structure, function and inhibition,” Biochemical Journal, vol. 357, no. 3, pp. 593–615, 2001. View at Publisher · View at Google Scholar
  47. S. Cheng, W. M. Yan, B. Yang, J. D. Shi, M. M. Song, and Y. Zhao, “A crucial role of nitric oxide in acute lung injury secondary to the acute necrotizing pancreatitis,” Human & Experimental Toxicology, vol. 29, no. 4, pp. 329–337, 2010. View at Publisher · View at Google Scholar · View at Scopus
  48. G. Özhan, F. M. Sari, M. Vefai, H. T. Yanar, and B. Alpertunga, “Acute pancreatitis is associated with Ser608Leu iNOS polymorphism,” Folia Biologica, vol. 58, no. 6, pp. 256–260, 2012. View at Google Scholar
  49. V. Pădureanu, I. StreaȚă, M. Ioana et al., “Determination of iNOS-2087A > G Polymorphism in Acute Pancreatitis Patients,” Current Health Sciences Journal, vol. 40, no. 4, pp. 249–252, 2014. View at Publisher · View at Google Scholar
  50. S. W. Seo, W. S. Jung, T. G. Piao et al., “Selective cyclooxygenase-2 inhibitor ameliorates cholecystokinin-octapeptide-induced acute pancreatitis in rats,” World Journal of Gastroenterology, vol. 13, no. 16, pp. 2298–2304, 2007. View at Publisher · View at Google Scholar
  51. G. Ozhan, T. H. Yanar, C. Ertekin, and B. Alpertunga, “The effect of genetic polymorphisms of cyclooxygenase 2 on acute pancreatitis in Turkey,” Pancreas, vol. 39, no. 3, pp. 371–376, 2010. View at Publisher · View at Google Scholar · View at Scopus
  52. A. J. Monsuur, P. I. de Bakker, B. Z. Alizadeh et al., “Myosin IXB variant increases the risk of celiac disease and points toward a primary intestinal barrier defect,” Nature Genetics, vol. 37, no. 12, pp. 1341–1344, 2005. View at Publisher · View at Google Scholar · View at Scopus
  53. A. A. van Bodegraven, C. R. Curley, K. A. Hunt et al., “Genetic variation in myosin IXB is associated with ulcerative colitis,” Gastroenterology, vol. 131, no. 6, pp. 1768–1774, 2006. View at Publisher · View at Google Scholar · View at Scopus
  54. R. M. Nijmeijer, H. C. van Santvoort, A. Zhernakova et al., “Association analysis of genetic variants in the myosin IXB gene in acute pancreatitis,” PLoS One, vol. 8, no. 12, article e85870, 2013. View at Publisher · View at Google Scholar · View at Scopus
  55. T. Grady, P. Liang, S. A. Ernst, and C. D. Logsdon, “Chemokine gene expression in rat pancreatic acinar cells is an early event associated with acute pancreatitis,” Gastroenterology, vol. 113, no. 6, pp. 1966–1975, 1997. View at Publisher · View at Google Scholar
  56. X. P. Zhang, L. Wang, and Y. F. Zhou, “The pathogenic mechanism of severe acute pancreatitis complicated with renal injury: a review of current knowledge,” Digestive Diseases and Sciences, vol. 53, no. 2, pp. 297–306, 2008. View at Publisher · View at Google Scholar · View at Scopus
  57. C. E. McNaught, N. P. Woodcock, C. J. Mitchell, G. Rowley, D. Johnstone, and J. MacFie, “Gastric colonisation, intestinal permeability and septic morbidity in acute pancreatitis,” Pancreatology, vol. 2, no. 5, pp. 463–468, 2002. View at Publisher · View at Google Scholar · View at Scopus
  58. T. Kawasaki and T. Kawai, “Toll-like receptor signaling pathways,” Frontiers in Immunology, vol. 5, p. 461, 2014. View at Publisher · View at Google Scholar · View at Scopus
  59. Y. Takagi, A. Masamune, K. Kume et al., “Microsatellite polymorphism in intron 2 of human Toll-like receptor 2 gene is associated with susceptibility to acute pancreatitis in Japan,” Human Immunology, vol. 70, no. 3, pp. 200–204, 2009. View at Publisher · View at Google Scholar · View at Scopus
  60. A. M. Matas-Cobos, E. Redondo-Cerezo, C. Alegría-Motte et al., “The role of Toll-like receptor polymorphisms in acute pancreatitis occurrence and severity,” Pancreas, vol. 44, no. 3, pp. 429–433, 2015. View at Publisher · View at Google Scholar · View at Scopus
  61. S. Akira, S. Uematsu, and O. Takeuchi, “Pathogen recognition and innate immunity,” Cell, vol. 124, no. 4, pp. 783–801, 2006. View at Publisher · View at Google Scholar · View at Scopus
  62. R. Landmann, B. Müller, and W. Zimmerli, “CD14, new aspects of ligand and signal diversity,” Microbes and Infection, vol. 2, no. 3, pp. 295–304, 2000. View at Publisher · View at Google Scholar · View at Scopus
  63. S. H. Rahman, G. Salter, J. H. Holmfield, M. Larvin, and M. J. McMahon, “Soluble CD14 receptor expression and monocyte heterogeneity but not the C-260T CD14 genotype are associated with severe acute pancreatitis,” Critical Care Medicine, vol. 32, no. 12, pp. 2457–2463, 2004. View at Publisher · View at Google Scholar · View at Scopus
  64. A. Masamune, K. Kume, K. Kikuta et al., “651C/T promoter polymorphism in the CD14 gene is associated with severity of acute pancreatitis in Japan,” Journal of Gastroenterology, vol. 45, no. 2, pp. 225–233, 2010. View at Publisher · View at Google Scholar · View at Scopus
  65. D. H. Adams and A. R. Lloyd, “Chemokines: leucocyte recruitment and activation cytokines,” The Lancet, vol. 349, no. 9050, pp. 490–495, 1997. View at Publisher · View at Google Scholar · View at Scopus
  66. T. Ishibashi, H. Zhao, K. Kawabe et al., “Blocking of monocyte chemoattractant protein-1 (MCP-1) activity attenuates the severity of acute pancreatitis in rats,” Journal of Gastroenterology, vol. 43, no. 1, pp. 79–85, 2008. View at Publisher · View at Google Scholar · View at Scopus
  67. W. C. Chen and J. S. Nie, “Genetic polymorphism of MCP-1-2518, IL-8-251 and susceptibility to acute pancreatitis: a pilot study in population of Suzhou, China,” World Journal of Gastroenterology, vol. 14, no. 37, pp. 5744–5748, 2008. View at Publisher · View at Google Scholar · View at Scopus
  68. F. Fang, J. Pan, L. Xu, G. Su, G. Li, and J. Wang, “Association between chemokine (C-C motif) ligand 2 gene -2518 A/G polymorphism and pancreatitis risk: a meta-analysis,” Pancreatology, vol. 15, no. 1, pp. 53–58, 2015. View at Publisher · View at Google Scholar · View at Scopus
  69. Z. Tiszlavicz, A. Szabolcs, T. Takács et al., “Polymorphisms of beta defensins are associated with the risk of severe acute pancreatitis,” Pancreatology, vol. 10, no. 4, pp. 483–490, 2010. View at Publisher · View at Google Scholar · View at Scopus
  70. Y. P. Huang, T. Y. Wang, W. Wang, and H. Z. Sun, “Association between genetic polymorphisms in DEFB1 and susceptibility to digestive diseases,” Medical Science Monitor, vol. 21, pp. 2240–2250, 2015. View at Publisher · View at Google Scholar · View at Scopus
  71. U. Holmskov, R. Malhotra, R. B. Sim, and J. C. Jensenius, “Collectins: collagenous C-type lectins of the innate immune defense system,” Immunology Today, vol. 15, no. 2, pp. 67–74, 1994. View at Publisher · View at Google Scholar · View at Scopus
  72. O. Neth, D. L. Jack, A. W. Dodds, H. Holzel, N. J. Klein, and M. W. Turner, “Mannose-binding lectin binds to a range of clinically relevant microorganisms and promotes complement deposition,” Infection and Immunity, vol. 68, no. 2, pp. 688–693, 2000. View at Publisher · View at Google Scholar · View at Scopus
  73. J. A. Summerfield, M. Sumiya, M. Levin, and M. W. Turner, “Association of mutations in mannose binding protein gene with childhood infection in consecutive hospital series,” BMJ, vol. 314, no. 7089, pp. 1229–1232, 1997. View at Publisher · View at Google Scholar
  74. P. Garred, H. O. Madsen, U. Balslev et al., “Susceptibility to HIV infection and progression of AIDS in relation to variant alleles of mannose-binding lectin,” The Lancet, vol. 349, no. 9047, pp. 236–240, 1997. View at Publisher · View at Google Scholar · View at Scopus
  75. D. Zhang, H. Zheng, Y. Zhou, B. Yu, and J. Li, “TLR and MBL gene polymorphisms in severe acute pancreatitis,” Molecular Diagnosis & Therapy, vol. 12, no. 1, pp. 45–50, 2008. View at Publisher · View at Google Scholar
  76. F. Bishehsari, A. Sharma, K. Stello et al., “TNF-alpha gene (TNFA) variants increase risk for multi-organ dysfunction syndrome (MODS) in acute pancreatitis,” Pancreatology, vol. 12, no. 2, pp. 113–118, 2012. View at Publisher · View at Google Scholar · View at Scopus
  77. D. Zhang, J. Li, Z. W. Jiang, B. Yu, and X. Tang, “Association of two polymorphisms of tumor necrosis factor gene with acute severe pancreatitis,” Journal of Surgical Research, vol. 112, no. 2, pp. 138–143, 2003. View at Publisher · View at Google Scholar · View at Scopus
  78. D. L. Zhang, J. S. Li, Z. W. Jiang, B. J. Yu, X. M. Tang, and H. M. Zheng, “Association of two polymorphisms of tumor necrosis factor gene with acute biliary pancreatitis,” World Journal of Gastroenterology, vol. 9, no. 4, pp. 824–828, 2003. View at Publisher · View at Google Scholar
  79. Z. Dianliang, L. Jieshou, J. Zhiwei, and Y. Baojun, “Association of plasma levels of tumor necrosis factor (TNF)-α and its soluble receptors, two polymorphisms of the TNF gene, with acute severe pancreatitis and early septic shock due to it,” Pancreas, vol. 26, no. 4, pp. 339–343, 2003. View at Publisher · View at Google Scholar · View at Scopus
  80. Y. Liu, G. Dan, L. Wu et al., “Functional effect of polymorphisms in the promoter of TNFAIP3 (A20) in acute pancreatitis in the Han Chinese population,” PLoS One, vol. 9, no. 7, article e103104, 2014. View at Publisher · View at Google Scholar · View at Scopus
  81. D. L. Zhang, H. M. Zheng, Y. BJ, Z. W. Jiang, and J. S. Li, “Association of polymorphisms of IL and CD14 genes with acute severe pancreatitis and septic shock,” World Journal of Gastroenterology, vol. 11, no. 28, pp. 4409–4413, 2005. View at Publisher · View at Google Scholar
  82. K. Sargen, A. G. Demaine, and A. N. Kingsnorth, “Cytokine gene polymorphisms in acute pancreatitis,” Journal of the Pancreas, vol. 1, no. 2, pp. 24–35, 2000. View at Publisher · View at Google Scholar
  83. H. K. Gao, Z. G. Zhou, Y. Li, and Y. Q. Chen, “Toll-like receptor 4 Asp299Gly polymorphism is associated with an increased risk of pancreatic necrotic infection in acute pancreatitis: a study in the Chinese population,” Pancreas, vol. 34, no. 3, pp. 295–298, 2007. View at Publisher · View at Google Scholar · View at Scopus