Helicobacter pylori Infection Is Associated with Type 2 Diabetes, Not Type 1 Diabetes: An Updated Meta-Analysis

Table 1

Characteristics of the included studies.

Author	Year	Country	Study design	Type of DM	Age (years)^♦	Method of detection	NOS
Han et al. [20]	2016	China	Cross-sectional	T2DM	64.1 ± 8.6	1	9
Kayar et al. [7]	2015	Turkey	Case-control	T2DM	18–65	2	7
Vafaeimanesh et al. [10]	2015	Iran	Cross-sectional	T2DM	52.84 ± 8.82	3	7
Zhou et al. [14]	2015	China	Case-control	T2DM	42.4 ± 9.8	3, 4	9
Qiao et al. [45]	2015	China	Case-control	T2DM	52.5 ± 1.7	1	7
Ji et al. [46]	2015	China	Case-control	T2DM	51.6 ± 12.5	1, 3	8
Bajaj et al. [9]	2014	India	Case-control	T2DM	≥18	3, 4, 5	8
Chobot et al. [47]	2014	Poland	Case-control	T1DM	13.4 ± 3.4	1	7
Sotuneh et al. [15]	2014	Iran	Cross-sectional	DM	Elderly	3	8
Yang et al. [11]	2014	Taiwan	Cross-sectional	T2DM	59.6 ± 10.0	5	9
Zhang et al. [48]	2014	China	Case-control	DM	52.14 ± 10.25	1	7
Wei et al. [49]	2014	China	Case-control	T2DM	52.79 ± 12.86	1	7
Ye and Xu [50]	2014	China	Case-control	T2DM	54.2 ± 2.0	1	7
Liu et al. [51]	2014	China	Case-control	T2DM	51–65	1	7
Zhou et al. [52]	2014	China	Case-control	T2DM	57.8 ± 11.7	1	7
Wang F and Wang XF [53]	2014	China	Case-control	T2DM	54.6 ± 1.4	1	7
Bai et al. [54]	2014	China	Case-control	T2DM	52.5 ± 14.2	1	7
Jia et al. [55]	2014	China	Case-control	DM	61.0 ± 10.0	1	6
Jafarzadeh et al. [56]	2013	Iran	Cross-sectional	DM	42.86 ± 6.42	3	7
Keramat et al. [57]	2013	Iran	Case-control	DM	51.20 ± 11.60	3, 4, 5	8
Xue et al. [58]	2013	China	Case-control	T2DM	57.03 ± 11.29	1	7
Luo H [59]	2013	China	Case-control	DM	51.5 ± 4.9	4	6
Candelli et al. [60]	2012	Italy	Prospective cohort	T1DM	19.8 ± 4.3	1	7
Jeon et al. [32]	2012	USA	Prospective cohort	DM	67.9 (64.1–71.3)	3	7
Oluyemi et al. [61]	2012	Nigeria	Cross-sectional	T2DM	56.4 ± 10.4	2	7
Hao et al. [62]	2012	China	Case-control	DM	47.24 ± 8.49	1	6
Xu et al. [63]	2012	China	Case-control	T2DM	61.0 ± 10.96	3	7
El-Eshmawy et al. [40]	2011	Egypt	Case-control	T1DM	19.35 ± 2.6	3	7
Wan et al. [64]	2011	China	Case-control	T2DM	53.4 ± 1.8	1	6
Chen et al. [65]	2011	China	Case-control	DM	53.0 ± 5.6	1	6
Agrawal et al. [66]	2010	India	Case-control	T2DM	—	5	7
Devrajani et al. [8]	2010	Pakistan	Case-control	T2DM	>35	2	7
Ibrahim et al. [44]	2010	Egypt	Case-control	T2DM	45 ± 5.4	4, 5, 6	6
Sfarti et al. [37]	2010	Romania	Case-control	T1DM	49.5 ± 14.2	1, 4, 5	7
Xu et al. [67]	2010	China	Case-control	T2DM	51.5 ± 13.0	1	7
Cabral et al. [68]	2009	Brazil	Case-control	T1DM	17.6 ± 1.5	5	6
Ciortescu et al. [69]	2009	Romania	Case-control	DM	—	1, 3, 5	^#
Krause et al. [38]	2009	Israel	Case-control	T1DM	16.0 ± 8.7	3	6
Lazaraki et al. [70]	2009	Greece	Case-control	T2DM	65.32 ± 8.56	4, 5	6
Zhang LQ and Zhang MQ [71]	2009	China	Case-control	T2DM	56.5 ± 1.1	1	7
Yu [72]	2009	China	Case-control	T2DM	52.5 ± 13.4	1	6
Ariizumi et al. [73]	2008	Japan	Case-control	DM	62.5 ± 11.5	3, 4, 5	6
Demir et al. [74]	2008	Turkey	Case-control	T2DM	52 ± 8.2	5	6
Hamed et al. [75]	2008	Egypt	Case-control	DM	47.65 ± 1.2	3	7
Nicholas et al. [76]	2008	Nigeria	Case-control	T2DM	29–72	3	7
Yan et al. [77]	2008	China	Case-control	T2DM	32–85	1	6
Wang et al. [78]	2008	China	Case-control	T2DM	47.1 ± 6.37	5	6
Ji YF et al. [79]	2008	China	Case-control	T2DM	55.2 ± 13.5	5	7
Bener et al. [80]	2007	Qatar	Case-control	T2DM	48.1 ± 7.9	3	7
Sun et al. [81]	2007	China	Case-control	T2DM	35–85	1	7
Jaber [82]	2006	Saudi Arabia	Case-control	T1DM	Children	3	7
Lu et al. [83]	2006	China	Case-control	T2DM	59.4 ± 11.2	3	7
Gulcelik et al. [84]	2005	Turkey	Case-control	T2DM	51.9 ± 10.6	5	7
Gillum [85]	2004	USA	Cross-sectional	DM	40–74	3	7
Candelli et al. [27]	2003	Italy	Case–control	T2DM	14.8 ± 5.6	1	6
Anastasios et al. [86]	2002	Greece	Cross-sectional	DM	61.4 ± 12.3	5	6
Cenerelli et al. [87]	2002	Italy	Case-control	T2DM	55.7 ± 9.7	1	7
Colombo et al. [88]	2002	Italy	Case-control	T1DM	Children	3	^#
De Block et al. [36]	2002	Belgium	Case-control	T1DM	41 ± 12	3, 5	7
Maule et al. [89]	2002	Italy	Case-control	T2DM	46–75	1	7
Zelenková et al. [90]	2002	Czech	Case-control	DM	—	3	^#
Ko et al. [91]	2001	China	Case-control	T2DM	49.9 ± 12.0	4	6
Ivandić et al. [92]	2001	Croatia	Case-control	DM	23–63	5	6
Ravera et al. [93]	2001	Uganda	Case-control	DM	—	5	6
Marrollo et al. [94]	2001	Italy	Case-control	DM	63	5	7
Quatrini et al. [95]	2001	Italy	Case-control	DM	58	1	7
Senturk et al. [39]	2001	Turkey	Case-control	T2DM	—	5, 6	^#
Vazeou et al. [96]	2001	UK	Case-control	T1DM	14.5	3	6
Xia [97]	2001	Australia	Case-control	DM	60.7 ± 13.3	3	7
Zhao [98]	2001	China	Case-control	T2DM	59.6 ± 1.3	1	6
Arslan et al. [99]	2000	Turkey	Case-control	T1DM	Children	3	^#
Dore et al. [100]	2000	Italy	Case-control	DM	12–75	3	6
Güvener et al. [101]	1999	Turkey	Case-control	T2DM	—	5	7
Salardi et al. [102]	1999	Italy	Case-control	T1DM	12	3	7
de Luis et al. [103]	1998	Spain	Case-control	DM	24.05 ± 8.3	3	6
Gasbarrini et al. [104]	1998	Italy	Case-control	DM	35 ± 11	1	7
Gentile et al. [105]	1998	Italy	Case-control	T2DM	51 ± 8	5	7
Pocecco et al. [106]	1997	Italy	Case-control	DM	16	4	6
Małlecki et al. [107]	1996	Poland	Case-control	DM	—	5	6

NOS: Newcastle-Ottawa scale. ^♦Mean age or the range of age in DM group. 1 = ¹³C or ¹⁴C urea breath test, 2 = stool antigen test, 3 = anti-H. pylori antibody, 4 = rapid urease test, 5 = histology or biopsy, 6 = culture. ^#Non-English or non-Chinese article or only abstract available which could not get the full text for scoring.