Prognostic Value of Metastatic Tumoral Caveolin-1 Expression in Patients with Resected Gastric Cancer

Table 3

Univariate and multivariate analyses of relapse-free survival rates using the Cox proportional hazards model in all patients.

Characteristics	Univariate analysis			Multivariate analysis
	Hazard ratio	95% CI	value	Hazard ratio	95% CI	value
Age (>60 versus ≤60 years)	1.623	0.982–2.683	0.059	2.158	1.207–3.862	0.009
Sex (female versus male)	0.804	0.45–1.439	0.463
Advanced T stage (pT4 versus pT2-3)	3.088	1.557–6.045	0.001	2.464	0.995–6.102	0.051
Advanced N stage (pN2-3 versus pN0-1)	3.688	2.157–6.304	<0.001	1.491	0.208–2.156	0.502
Lauren classification (diffuse versus nondiffuse)	1.505	0.905–2.501	0.115	1.917	1.032–3.562	0.039
Lymphatic invasion (yes versus no)	2.956	1.272–6.869	0.012	1.479	0.543–0.032	0.444
Venous invasion (yes versus no)	1.821	0.782–4.238	0.165	0.483	0.778–5.498	0.145
Tumor grade (moderate–poor versus well)	4.199	1.026–17.184	0.046	1.754	0.112–2.911	0.498
Adjuvant chemotherapy (yes versus no)	0.839	0.51–1.381	0.490
LNR (>median versus ≤median)	4.551	2.567–8.069	<0.001	2.282	0.926–5.626	0.072
Tumoral Cav-1 expression, primary tumor (high versus low)	0.95	0.452–1.996	0.892	1.275	0.485–3.350	0.622
Stromal Cav-1 expression, primary tumor (high versus low)	1.529	0.881–2.652	0.131	0.956	0.516–2.116	0.902
Tumoral Cav-1 expression, lymph node (high versus low)	2.874	1.491–5.540	0.002	3.934	1.882–8.224	<0.001

LNR: lymph node ratio.