Prognostic Value of Metastatic Tumoral Caveolin-1 Expression in Patients with Resected Gastric Cancer

Table 4

Univariate and multivariate analyses by cancer-specific survival rates using the Cox proportional hazards model in all patients.

Characteristics	Univariate analysis			Multivariate analysis
	Hazard ratio	95% CI	value	Hazard ratio	95% CI	value
Age (>60 versus ≤60)	1.143	0.623–2.095	0.666
Sex (female versus male)	0.9	0.452–1.792	0.765
Advanced T stage (pT4 versus pT2-3)	3.452	1.453–8.202	0.005	3.366	1.010–11.214	0.048
Advanced N stage (pN2-3 versus pN0-1)	4.344	2.214–8.522	<0.001	1.919	0.147–1.838	0.310
Lauren classification (diffuse versus nondiffuse)	1.532	0.827–2.838	0.175	0.506	0.928–4.204	0.077
Lymphatic invasion (yes versus no)	12.903	1.774–93.854	0.012	5.759	0.718–46.228	0.099
Venous invasion (yes versus no)	2.744	1.149–6.553	0.023	0.380	0.990–6.990	0.052
Tumor grade (moderate–poor versus well)	2.866	0.692–11.86	0.146	2.983	0.057–1.970	0.226
Adjuvant chemotherapy (yes versus no)	0.794	0.433–1.454	0.454
LNR (>median versus ≤median)	6.476	2.987–14.042	<0.001	0.2662	1.122–12.579	0.031
Tumoral Cav-1 expression, primary tumor (high versus low)	0.496	0.153–1.605	0.242	0.3945	0.084–1.849	0.237
Stromal Cav-1 expression, primary tumor (high versus low)	1.48	0.756–2.897	0.253
Tumoral Cav-1 expression, lymph node (high versus low)	3.064	1.429–6.569	0.004	2.681	1.612–8.623	0.002

LNR: lymph node ratio.