Prognostic Value of Metastatic Tumoral Caveolin-1 Expression in Patients with Resected Gastric Cancer

Table 5

Univariate and multivariate analyses of relapse-free survival rates using the Cox proportional hazards model in patients with metastatic lymph nodes.

Characteristics	Univariate analysis			Multivariate analysis
	Hazard ratio	95% CI	value	Hazard ratio	95% CI	value
Age (>60 versus ≤60 years)	2.254	1.295–3.922	0.004	2.252	1.251–4.052	0.006
Sex (female versus male)	1.331	0.722–2.453	0.360
Advanced T stage (pT4 versus pT2-3)	2.414	1.030–5.655	0.042	2.750	1.110–6.810	0.028
Advanced N stage (pN2-3 versus pN1)	2.064	1.059–4.022	0.033	1.767	0.535–5.834	0.350
Lauren classification (diffuse versus nondiffuse)	1.411	0.809–2.462	0.225
Lymphatic invasion (yes versus no)	1.103	0.344–3.542	0.869
Venous invasion (yes versus no)	1.512	0.644–3.552	0.343
Tumor grade (moderate–poor versus well)	1.429	0.348–5.876	0.620
Adjuvant chemotherapy (yes versus no)	0.450	0.262–0.775	0.004	0.517	0.266–1.002	0.050
LNR (>median versus ≤median)	2.910	1.309–6.468	0.009	2.154	0.873–5.315	0.095
Tumoral Cav-1 expression, primary tumor (high versus low)	1.090	0.466–2.551	0.842	0.793	0.264–2.383	0.680
Stromal Cav-1 expression, primary tumor (high versus low)	1.354	0.751–2.441	0.313	1.122	0.575–2.186	0.735
Tumoral Cav-1 expression, lymph node (high versus low)	2.79	1.447–5.379	0.002	3.136	1.444–6.810	0.003

LNR: lymph node ratio.