Review Article

Probiotics Reduce Postoperative Infections in Patients Undergoing Colorectal Surgery: A Systematic Review and Meta-Analysis

Table 1

Characteristics of included studies.

StudyParticipants T/CAge (years) (Mean ± SD)InterventionDuration of treatmentProbiotic bacteriaJadad score
TCTC

Consoli et al. [23]15/1851.5 ± 13.954.5 ± 16.5Probiotics + antibiotics + MBPPlacebo + antibiotics + MBP9 d preoperativelyS. boulardii5
Kotzampassi et al. [20]84/8065.9 ± 11.566.4 ± 11.9Probiotics + MBPPlacebo + MBP1 d preoperatively
and 15 d postoperatively
L. acidophilus
L. plantarum
B. lactis
S. boulardii
4
Komatsu et al. [24]168/19466.7 ± 11.667.7 ± 10.7Synbiotics + antibiotics + MBPPlacebo + antibiotics + MBP7–11 d preoperatively
and 2–7 d postoperatively
L. casei
B. breve
3
Sadahiro et al. [25]100/9567 ± 966 ± 12Probiotics + antibiotics + MBPPlacebo + antibiotics + MBP7 d preoperatively
and 6 d postoperatively
B. bifidum4
Liu et al. [21]75/7562.3 ± 12.466.1 ± 11.0Probiotics + antibiotics + MBPPlacebo + antibiotics + MBP6 d preoperatively
and 10 d postoperatively
L. plantarum
L. acidophilus
B. longum
5
Zhang et al. [22]30/3067.5 ± 10.561.5 ± 9.0Probiotics + antibiotics + MBPPlacebo + antibiotics + MBP3 d preoperativelyB. longum
L. acidophilus
E. faecalis
3
Liu et al. [32]50/5065.3 ± 11.065.7 ± 9.9Probiotics + antibiotics + MBPPlacebo + antibiotics + MBP6 d preoperatively
and 10 d postoperatively
L. plantarum
L. acidophilus
B. longum
5
Horvat et al. [26]20/2063.0 ± 11.065.0 ± 6.5Synbiotics + antibiotics + MBPPlacebo + antibiotics + MBP3 d preoperativelyP. pentosaceus
L. mesenteroides
L. paracasei
L. plantarum
5
Reddy et al. [27]20/2268.4 ± 2.969.8 ± 7.0Synbiotics + antibiotics + MBPPlacebo + antibiotics + MBPNo dataL. acidophilus
L. bulgaricus
B. lactis
S. thermophilus
3

MBP: mechanical bowel preparation; L.: Lactobacillus; B.: Bifidobacterium; P.: Pediacoccus; E.: Enterococcus; S.: Streptococcus.