Tumor Budding, uPA, and PAI-1 in Colorectal Cancer: Update of a Prospective Study
Table 2
Clinicopathological data: validation set.
Complete collection
uPA low
uPA high
value
PAI-1 low
PAI-1 high
value
Budding low ()
Budding high ()
value
Mean age ± SD
68 ± 11
68 10
67 12
1.0
68 11
67 12
0.753
69 11
64 11
0.091
Gender m : f
1 : 0.9
1 : 0.74
1 : 1.15
0.514
1 : 0.7
1 : 1.4
0.262
1 : 1.2
1 : 0.3
0.05
Right colon
32 (47%)
17 (43%)
15 (54%)
21 (48%)
11 (46%)
26 (51%)
6 (35%)
Left colon
18 (26%)
11 (28%)
7 (25%)
9 (20%)
9 (38%)
16 (31%)
2 (12%)
Total colon
3 (4%)
1 (3%)
2 (7%)
1 (2%)
2 (8%)
1 (2%)
2 (12%)
Rectum
15 (22%)
11 (28%)
4 (14%)
13 (30%)
2 (8%)
8 (16%)
7 (41%)
Conventional histological type
56 (82%)
38 (95%)
18 (64%)
42 (95%)
14 (58%)
42 (82%)
14 (82%)
Mucinous type
8 (12%)
1 (3%)
7 (25%)
1 (2%)
7 (29%)
6 (12%)
2 (12%)
Medullary type
1 (1%)
0 (0%)
1 (4%)
0 (0%)
1 (4%)
1 (2%)
0 (0%)
Micropapillary type
3 (4%)
1 (3%)
2 (7%)
1 (2%)
2 (8%)
<
2 (4%)
1 (6%)
Infiltrative
6 (9%)
6 (15%)
0 (0%)
0.164
6 (14%)
0 (0%)
0.083
3 (6%)
3 (18%)
0.160
pT 1/2
16 (24%)
13 (33%)
3 (11%)
16 (36%)
0 (0%)
14 (27%)
2 (12%)
pT 3/4
52 (76%)
27 (68%)
25 (89%)
0.073
28 (64%)
24 (100%)
0.002
37 (73%)
15 (88%)
0.322
Grading: low grade
53 (78%)
36 (90%)
17 (61%)
39 (89%)
14 (58%)
41 (80%)
12 (71%)
Grading: high grade
15 (22%)
4 (10%)
11 (39%)
0.01
5 (11%)
10 (42%)
0.01
10 (20%)
5 (29%)
0.501
Node positive
38 (56%)
21 (53%)
17 (61%)
0.404
22 (50%)
16 (67%)
0.286
25 (49%)
13 (76%)
0.091
Lymphatic invasion
15 (22%)
10 (25%)
5 (18%)
0.563
9 (20%)
6 (25%)
0.762
8 (16%)
7 (41%)
0.043
Venous invasion
11 (16%)
6 (15%)
5 (18%)
0.319
6 (14%)
5 (21%)
0.500
5 (10%)
6 (35%)
0.022
Perineural invasion
10 (15%)
5 (13%)
5 (18%)
0.730
7 (16%)
3 (13%)
1.000
6 (12%)
4 (24%)
0.254
Strong chronic inflammation
13 (19%)
6 (15%)
7 (25%)
0.357
10 (23%)
3 (13%)
0.355
13 (25%)
0 (0%)
0.028
MSI/MMRd
9 (13%)
3 (8%)
6 (21%)
0.146
5 (11%)
4 (17%)
0.710
9 (18%)
0 (0%)
0.099
Metastatic disease
13 (19%)
5 (13%)
8 (29%)
0.124
6 (14%)
7 (29%)
0.195
5 (10%)
8 (47%)
0.002
Mean LN, number ± SD
43 17
44 20
42 12
0.837
42 19
45 13
0.068
43 18
42 16
0.949
Neoadjuvant therapy
4 (36%)
3 (75%)
6 (46%)
1 (50%)
3 (38%)
4 (57%)
SD, standard deviation; LN, lymph nodes. includes all locations (right, left, total, and rectum). versus nonrectal cancers. versus group of nonconventional types. to Jass [5]. is the number of rectal cancers.
