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Gastroenterology Research and Practice
Volume 2017, Article ID 7089697, 8 pages
https://doi.org/10.1155/2017/7089697
Research Article

Gastroprotective Value of Berries: Evidences from Methanolic Extracts of Morus nigra and Rubus niveus Fruits

1Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade do Vale do Itajaí (UNIVALI), Rua Uruguai, 458, Centro, 88302-202 Itajaí, SC, Brazil
2Graduação em Biomedicina, UNIVALI, Rua Uruguai, 458, Centro, 88302-202 Itajaí, SC, Brazil
3Programa de Pós-Graduação em Ciências Farmacêuticas, UNIVALI, Rua Uruguai, 458, Centro, 88302-202 Itajaí, SC, Brazil

Correspondence should be addressed to Sérgio Faloni Andrade; rb.ilavinu@inolaf

Received 28 April 2017; Accepted 22 August 2017; Published 20 September 2017

Academic Editor: Kazuhiko Uchiyama

Copyright © 2017 Luciane Angela Nottar Nesello et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P. B. Yazbek, A. B. Trindade, C. M. Chin, and J. L. Dos Santos, “Challenges to the treatment and new perspectives for the eradication of Helicobacter pylori,” Digestive Diseases and Sciences, vol. 60, no. 10, pp. 2901–2912, 2015. View at Publisher · View at Google Scholar · View at Scopus
  2. J. Y. Lau, A. Barkun, D. M. Fan, E. J. Kuipers, Y. S. Yang, and F. K. Chan, “Challenges in the management of acute peptic ulcer bleeding,” Lancet, vol. 381, no. 9882, pp. 2033–2043, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. J. L. Goldstein, “Challenges in managing NSAID-associated gastrointestinal tract injury,” Digestion, vol. 69, no. 1, pp. 25–33, 2004. View at Publisher · View at Google Scholar · View at Scopus
  4. L. Laine, K. Takeuchi, and A. Tarnawki, “Gastric mucosal defense and cytoprotection: bench to bedside,” Gastroenterology, vol. 135, pp. 41–60, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. R. O. Nneli, W. C. Nwafia, and J. O. Orji, “Diets/dietary habits and certain gastrointestinal disorders in the tropics: a review,” Nigerian Journal of Physiological Sciences, vol. 22, no. 1-2, pp. 1–13, 2010. View at Publisher · View at Google Scholar
  6. E. U. Nwose and K. C. Yee, “Drug-disease interactions: narrative review of aspirin in gastric ulcer,” Expert Opinion on Drug Metabolism & Toxicology, vol. 12, no. 9, pp. 1081–1087, 2016. View at Publisher · View at Google Scholar · View at Scopus
  7. A. Franke, S. Teyssen, and M. V. Singer, “Alcohol-related diseases of the esophagus and stomach,” Digestive Diseases, vol. 23, no. 3-4, pp. 204–213, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. M. P. Dore, G. M. Pes, G. Bassotti, and P. Usai-Satta, “Dyspepsia: when and how to test for Helicobacter pylori infection,” Gastroenterology Research and Practice, vol. 2016, Article ID 8463614, 9 pages, 2016. View at Publisher · View at Google Scholar · View at Scopus
  9. L. Y. Yu, L. N. Sun, X. H. Zhang et al., “A review of the novel application and potential adverse effects of proton pump inhibitors,” Advances in Therapy, vol. 34, 2017. View at Publisher · View at Google Scholar
  10. N. Kangwan, J. M. Park, E. H. Kim, and K. B. Hahm, “Quality of healing of gastric ulcers: natural products beyond acid suppression,” World Journal of Gastrointestinal Pathophysiology, vol. 5, pp. 40–47, 2014. View at Publisher · View at Google Scholar
  11. N. Deighton, R. Brennan, C. Finn, and H. V. Davies, “Antioxidant properties of domesticated and wild Rubus species,” Journal of the Science of Food and Agriculture, vol. 80, pp. 1307–1313, 2000. View at Google Scholar
  12. M. Gundogdu, F. Muradoglu, R. I. Gazioglu Sensoy, and H. Yilmaz, “Determination of fruit chemical properties of Morus nigra L., Morus alba L. and Morus rubra L. by HPLC,” Scientia Horticulturae, vol. 132, pp. 37–41, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. S. Skrovankova, D. Sumczynski, J. Mlcek, T. Jurikova, and J. Sochor, “Bioactive compounds and antioxidant activity in different types of berries,” International Journal of Molecular Sciences, vol. 16, no. 10, pp. 24673–24706, 2015. View at Publisher · View at Google Scholar · View at Scopus
  14. Brasil. Ministério da Saúde. Direção de Administração e Finanças. Secretaria de Ciência, Tecnologia e Insumos Estratégicos, “RENISUS - Relação Nacional de Plantas Medicinais de Interesse ao SUS,” 2009. 1 p. April 2017, http://portalarquivos.saude.gov.br/images/pdf/2014/maio/07/renisus.pdf.
  15. V. Cechinel Filho and R. A. Yunes, “Estratégias para a obtenção de compostos farmacologicamente ativos a partir de plantas medicinais: conceitos sobre modificação estrutural para otimização da atividade,” Química Nova, vol. 21, no. 1, pp. 99–105, 1998. View at Publisher · View at Google Scholar
  16. A. Arnous, D. P. Makris, and P. Kefalas, “Effect of principal polyphenolic components in relation to antioxidant characteristics of aged red wines,” Journal of Agricultural and Food Chemistry, vol. 49, pp. 5736–5742, 2001. View at Publisher · View at Google Scholar · View at Scopus
  17. A. Arvouet-Grand, B. Vennat, A. Pourrat, and P. Legret, “Standardization of propolis extract and identification of principal constituents,” Journal de Pharmacie de Belgique, vol. 49, no. 6, pp. 462–468, 1994. View at Google Scholar
  18. L. M. Da Silva, T. Boeing, L. B. Somensi et al., “Evidence of gastric ulcer healing activity of Maytenus robusta Reissek: in vitro and in vivo studies,” Journal of Ethnopharmacology, vol. 175, pp. 75–85, 2015. View at Publisher · View at Google Scholar · View at Scopus
  19. A. P. Beber, P. de Souza, T. Boeing et al., “Constituents of leaves from Bauhinia curvula Benth. exert gastroprotective activity in rodents: role of quercitrin and kaempferol,” Inflammopharmacology, 2017, in press. View at Publisher · View at Google Scholar
  20. Z. Y. Jiang, J. V. Hunt, and S. P. Wolff, “Ferrous ion oxidation in the presence of xylenol orange for detection of lipid hydroperoxide in low density lipoprotein,” Analytical Biochemistry, vol. 202, pp. 384–389, 1992. View at Publisher · View at Google Scholar · View at Scopus
  21. J. Sedlack and R. H. Lindsay, “Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman’s reagent,” Analytical Biochemistry, vol. 24, no. 1, pp. 192–205, 1968. View at Publisher · View at Google Scholar
  22. K. Kubo, H. Uehara, T. Kubota et al., “Effects of ranitidine on gastric vesicles containing H+, K+-adenosine triphosphatase in rats,” Scandinavian Journal of Gastroenterology, vol. 30, pp. 944–951, 1995. View at Publisher · View at Google Scholar · View at Scopus
  23. M. A. Quadri and R. K. Srivastava, “Micro-determination of inorganic phosphorus and alkaline phosphatase activity in biological fluids,” Archiv für Experimentelle Veterinärmedizin, vol. 34, no. 5, pp. 667–672, 1980. View at Google Scholar
  24. S. N. Jimenez-Garcia, R. G. Guevara-Gonzalez, R. Miranda-Lopez, A. A. Feregrino-Perez, I. Torres-Pacheco, and M. A. Vazquez-Cruz, “Functional properties and quality characteristics of bioactive compounds in berries: biochemistry, biotechnology, and genomics,” Food Research International, vol. 54, no. 1, pp. 1195–1207, 2013. View at Publisher · View at Google Scholar · View at Scopus
  25. R. Z. Feng, Q. Wang, W. Z. Tong et al., “Extraction and antioxidant activity of flavonoids of Morus nigra,” International Journal of Clinical and Experimental Medicine, vol. 8, no. 12, pp. 22328–22336, 2015. View at Google Scholar
  26. M. Fritsch, A. Bohn, F. Kuhn, J. Scapinello, and J. Dal Magro, “Caracterização da atividade antioxidante de frutas silvestres da região Sul do Brasil,” Anais do XX Congresso Brasileiro de Engenharia Química, vol. 1, no. 2, pp. 1–7, 2015. View at Publisher · View at Google Scholar
  27. M. Özgen, S. Serçe, and C. Kaya, “Phytochemical and antioxidant properties of anthocyanin-rich Morus nigra and Morus rubra fruits,” Scientia Horticulturae, Turquia, vol. 119, no. 3, pp. 275–279, 2009. View at Publisher · View at Google Scholar · View at Scopus
  28. A. M. Pawlowska, W. Oleszek, and A. Braca, “Quali-quantitative analyses of flavonoids of Morus nigra L. and Morus alba L. (Moraceae) fruits,” Journal of Agricultural and Food Chemistry, vol. 56, no. 9, pp. 3377–3380, 2008. View at Publisher · View at Google Scholar · View at Scopus
  29. S. H. Fang, Y. C. Hou, and P. D. L. Chao, “Pharmacokinetic and pharmacodynamic interactions of morin and cyclosporine,” Toxicology and Applied Pharmacology, vol. 205, no. 1, pp. 65–70, 2005. View at Publisher · View at Google Scholar · View at Scopus
  30. A. C. Jacques and R. C. Zambiazi, “Fitoquímicos em amora-preta (Rubus spp),” Semina: Ciências Agrárias, vol. 32, no. 1, pp. 245–260, 2011. View at Publisher · View at Google Scholar
  31. W. Mullen, J. McGinn, M. E. Lean et al., “Ellagitannins, flavonoids, and other phenolics in red raspberries and their contribution to antioxidant capacity and vasorelaxation properties,” Journal of Agricultural and Food Chemistry, vol. 50, pp. 5191–5196, 2002. View at Publisher · View at Google Scholar · View at Scopus
  32. G. J. McDougall, H. A. Ross, M. Ikeji, and D. Stewart, “Berry extracts exert different antiproliferative effects against cervical and colon cancer cells grown in vitro,” Journal of Agricultural and Food Chemistry, vol. 56, pp. 3016–3023, 2008. View at Publisher · View at Google Scholar · View at Scopus
  33. H. A. Ross, G. J. McDougall, and D. Stewart, “Antiproliferative activity is predominantly associated with ellagitannins in raspberry extracts,” Phytochemistry, vol. 68, pp. 218–228, 2007. View at Publisher · View at Google Scholar · View at Scopus
  34. S. Zafra-Stone, T. Yasmin, M. Bagchi, A. Chatterjee, J. A. Vinson, and D. Bagchi, “Berry anthocyanins as novel antioxidants in human health and disease prevention,” Molecular Nutrition & Food Research, vol. 51, no. 6, pp. 675–683, 2007. View at Publisher · View at Google Scholar · View at Scopus
  35. E. Sangiovanni, U. Vrhovsek, G. Rossoni et al., “Ellagitannins from Rubus berries for the control of gastric inflammation: in vitro and in vivo studies,” PLoS One, vol. 8, no. 8, article e71762, 2013. View at Publisher · View at Google Scholar · View at Scopus
  36. J. H. Nam, H. J. Jung, J. Choi, K. T. Lee, and H. J. Park, “The anti-gastropathic and anti-rheumatic effect of niga-ichigoside F1 and 23-hydroxytormentic acid isolated from the unripe fruits of Rubus coreanus in a rat model,” Biological & Pharmaceutical Bulletin, vol. 29, no. 5, pp. 967–970, 2006. View at Publisher · View at Google Scholar · View at Scopus
  37. S. J. Kim, H. J. Lee, B. S. Kim et al., “Antiulcer activity of anthocyanins from Rubus coreanus via association with regulation of the activity of matrix metalloproteinase-2,” Journal of Agricultural and Food Chemistry, vol. 59, no. 21, pp. 11786–11793, 2011. View at Publisher · View at Google Scholar · View at Scopus
  38. E. Espada-Bellido, M. Ferreiro-González, C. Carrera, M. Palma, C. G. Barroso, and G. F. Barbero, “Optimization of the ultrasound-assisted extraction of anthocyanins and total phenolic compounds in mulberry (Morus nigra) pulp,” Food Chemistry, vol. 219, pp. 23–32, 2017. View at Publisher · View at Google Scholar
  39. M. H. Farzaei, M. Abdollahi, and R. Rahimi, “Role of dietary polyphenols in the management of peptic ulcer,” World Journal of Gastroenterology, vol. 21, no. 21, pp. 6499–6517, 2015. View at Publisher · View at Google Scholar · View at Scopus
  40. K. S. Mota, G. E. Dias, M. E. Pinto et al., “Flavonoids with gastroprotective activity,” Molecules, vol. 14, no. 3, pp. 979–1012, 2009. View at Publisher · View at Google Scholar · View at Scopus
  41. F. Schlickmann, L. Mota da Silva, T. Boeing et al., “Gastroprotective bio-guiding study of fruits from Mimusops balata,” Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 388, no. 11, pp. 1187–1200, 2015. View at Publisher · View at Google Scholar · View at Scopus
  42. M. de Barros, L. Mota da Silva, T. Boeing et al., “Pharmacological reports about gastroprotective effects of methanolic extract from leaves of Solidago chilensis (Brazilian arnica) and its components quercitrin and afzelin in rodents,” Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 389, no. 4, pp. 403–417, 2016. View at Publisher · View at Google Scholar · View at Scopus
  43. M. Oroian and I. Escriche, “Antioxidants: characterization, natural sources, extraction and analysis,” Food Research International, vol. 74, pp. 10–36, 2015. View at Publisher · View at Google Scholar · View at Scopus
  44. M. Arfan, R. Khan, A. Rybarczyk, and R. Amarowicz, “Antioxidant activity of mulberry fruit extracts,” International Journal of Molecular Sciences, vol. 13, no. 2, pp. 2472–2480, 2012. View at Publisher · View at Google Scholar · View at Scopus
  45. R. Caindan, L. Cairang, J. Pengcuo, and L. Tong, “Comparison of compounds of three Rubus species and their antioxidant activity,” Drug Discoveries & Therapeutics, vol. 9, no. 6, pp. 391–396, 2015. View at Publisher · View at Google Scholar · View at Scopus
  46. M. Ahmad, S. Masood, S. Sultana, T. B. Hadda, A. Bader, and M. Zafar, “Report: antioxidant and nutraceutical value of wild medicinal Rubus berries,” Pakistan Journal of Pharmaceutical Sciences, vol. 28, no. 1, pp. 241–247, 2015. View at Google Scholar
  47. S. Pérez, R. Taléns-Visconti, S. Rius-Pérez, I. Finamor, and J. Sastre, “Redox signaling in the gastrointestinal tract,” Free Radical Biology & Medicine, vol. 104, pp. 75–103, 2017. View at Publisher · View at Google Scholar
  48. S. V. Siegmund, S. Haas, and M. V. Singer, “Animal models and their results in gastrointestinal alcohol research,” Digestive Diseases, vol. 23, no. 3-4, pp. 181–194, 2006. View at Publisher · View at Google Scholar · View at Scopus
  49. H. Chen, J. Pu, D. Liu et al., “Anti-inflammatory and antinociceptive properties of flavonoids from the fruits of black mulberry (Morus nigra L.),” PLoS One, vol. 11, no. 4, article e0153080, 2016. View at Publisher · View at Google Scholar · View at Scopus
  50. H. Yandrapu and J. Sarosiek, “Protective factors of the gastric and duodenal mucosa: an overview,” Current Gastroenterology Reports, vol. 17, no. 6, p. 24, 2015. View at Publisher · View at Google Scholar · View at Scopus
  51. S. Kumardas and D. M. Vasudevan, “Alcohol-induced oxidative stress,” Life Sciences, vol. 81, no. 3, pp. 177–187, 2007. View at Publisher · View at Google Scholar · View at Scopus
  52. Y. Naito, T. Takagi, O. Handa, and T. Yoshikawa, “Lipid hydroperoxide-derived modification of proteins in gastrointestinal tract,” Sub-Cellular Biochemistry, vol. 77, pp. 137–148, 2014. View at Publisher · View at Google Scholar · View at Scopus
  53. S. Aydin, O. Yilmaz, and Z. Gokçe, “Protective effect of Morus nigra L. (mulberry) fruit extract on the liver fatty acid profile of Wistar rats,” Pakistan Journal Zoology, vol. 47, no. 1, pp. 255–261, 2015. View at Google Scholar