Table of Contents Author Guidelines Submit a Manuscript
Gastroenterology Research and Practice
Volume 2017, Article ID 7150386, 11 pages
https://doi.org/10.1155/2017/7150386
Review Article

Association between HLA-DQ Gene Polymorphisms and HBV-Related Hepatocellular Carcinoma

1Department of Biochemistry and Molecular Biology, Bengbu Medical College, Bengbu 233003, China
2Department of Clinical Laboratory, Bengbu Medical College, Bengbu, Anhui 233030, China
3Department of Microbiology and Immunology, Medical School of Southeast University, Nanjing, Jiangsu 210009, China
4Clinical Testing and Diagnose Experimental Center of Bengbu Medical College, Bengbu, Anhui 233030, China
5Department of Immunology, Bengbu Medical College, Bengbu Anhui 233030, China
6Anhui Key Laboratory of Infection and Immunity, Bengbu Medical College, Bengbu Anhui 233030, China

Correspondence should be addressed to Hongtao Wang; moc.621@oatgnohgnaw_bb

Received 27 March 2017; Revised 23 May 2017; Accepted 8 June 2017; Published 6 July 2017

Academic Editor: Tatsuya Toyokawa

Copyright © 2017 Jingzhu Lv et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. L. Siegel, K. D. Miller, and A. Jemal, “Cancer statistics, 2015,” CA: A Cancer Journal for Clinicians, vol. 65, no. 1, pp. 5–29, 2015. View at Publisher · View at Google Scholar · View at Scopus
  2. J. Ferlay, D. M. Parkin, M. P. Curado et al., Cancer Incidence in five Continents, Volumes I to X: IARC CANCER Base No. 10, 2014, http://ci5.iarc.fr.
  3. K. A. McGlynn, J. L. Petrick, and W. T. London, “Global epidemiology of hepatocellular carcinoma: an emphasis on demographic and regional variability,” Clinics in Liver Disease, vol. 19, no. 2, pp. 223–238, 2015. View at Publisher · View at Google Scholar · View at Scopus
  4. K. A. McGlynn and W. T. London, “The global epidemiology of hepatocellular carcinoma: present and future,” Clinics in Liver Disease, vol. 15, no. 2, pp. 223–243, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. D. M. Parkin, F. Bray, J. Ferlay, and P. Pisani, “Global cancer statistics, 2002,” CA: A Cancer Journal for Clinicians, vol. 55, pp. 74–108, 2005. View at Publisher · View at Google Scholar
  6. V. A. McCormack and P. Boffetta, “Today’s lifestyles, tomorrow’s cancers: trends in lifestyle risk factors for cancer in low- and middle-income countries,” Annals of Oncology, vol. 22, no. 11, pp. 2349–2357, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. J. D. Yang and L. R. Roberts, “Hepatocellular carcinoma: a global view,” Nature Reviews Gastroenterology & Hepatology, vol. 7, no. 8, pp. 448–458, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. M. J. Bouchard and S. Navas-Martin, “Hepatitis B and C virus hepatocarcinogenesis: lessons learned and future challenges,” Cancer Letters, vol. 305, no. 2, pp. 123–143, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. Y. Zheng, J. Huang, M. Zhan et al., “Genetic variants in the KDR gene is associated with the prognosis of transarterial chemoembolization treated hepatocellular carcinoma,” Tumor Biology, vol. 35, no. 11, pp. 11473–11481, 2014. View at Publisher · View at Google Scholar · View at Scopus
  10. K. Ye, S. Chang, J. Li, X. Li, Y. Zhou, and Z. Wang, “A functional and protein-protein interaction analysis of neuroepithelial cell transforming gene 1 in hepatocellular carcinoma,” Tumor Biology, vol. 35, no. 11, pp. 11219–11227, 2014. View at Publisher · View at Google Scholar · View at Scopus
  11. Y. Lu, Z. Wu, Q. Peng et al., “Role of IL-4 gene polymorphisms in HBV-related hepatocellular carcinoma in a Chinese population,” PloS One, vol. 9, no. 10, article e110061, 2014. View at Google Scholar
  12. R. Singh, R. Kaul, A. Kaul, and K. Khan, “A comparative review of HLA associations with hepatitis B and C viral infections across global populations,” World Journal of Gastroenterology, vol. 13, no. 12, pp. 1770–1787, 2007. View at Publisher · View at Google Scholar
  13. L. Hu, X. Zhai, J. Liu et al., “Genetic variants in human leukocyte antigen/DP-DQ influence both hepatitis B virus clearance and hepatocellular carcinoma development,” Hepatology, vol. 55, no. 5, pp. 1426–1431, 2012. View at Publisher · View at Google Scholar · View at Scopus
  14. K. Chen, W. Shi, Z. Xin et al., “Replication of genome wide association studies on hepatocellular carcinoma susceptibility loci in a Chinese population,” PloS One, vol. 8, no. 10, article e77315, 2013. View at Google Scholar
  15. V. Kumar, N. Kato, Y. Urabe et al., “Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma,” Nature Genetics, vol. 43, no. 5, pp. 455–458, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. A. A. Al-Qahtani, M. R. Al-Anazi, A. A. Abdo et al., “Association between HLA variations and chronic hepatitis B virus infection in Saudi Arabian patients,” PloS One, vol. 9, no. 1, article e80445, 2014. View at Google Scholar
  17. S. H. Hou, J. Hu, Y. Zhang, Q. L. Li, and J. J. Guo, “Effects of interaction between genetic variants in human leukocyte antigen DQ and granulysin genes in Chinese Han subjects infected with hepatitis B virus,” Microbiology and Immunology, vol. 59, no. 4, pp. 209–218, 2015. View at Publisher · View at Google Scholar · View at Scopus
  18. X. Gao, W. Liu, X. Zhang et al., “Genetic polymorphism of HLA-DQ confers susceptibility to hepatitis B virus-related hepatocellular carcinoma: a case-control study in Han population in China,” Tumor Biology, vol. 37, no. 9, pp. 12103–12111, 2016. View at Publisher · View at Google Scholar · View at Scopus
  19. W. X. Liu, X. L. Zhang, X. Gao, L. Yang, B. Li, and D. Liu, “Association between HLA-DQ gene polymorphisms and different outcomes of hepatitis B virus infection,” Chinese Journal of Epidemiology, vol. 37, no. 3, pp. 384–388, 2016, (Chinese). View at Google Scholar
  20. G. Diaz, M. Amicosante, D. Jaraquemada et al., “Functional analysis of HLA-DP polymorphism: a crucial role for DP beta residues 9, 11, 35, 55, 56, 69, and 84-87 in T cell allorecognition and peptide binding,” International Immunology, vol. 15, no. 5, pp. 565–576, 2003. View at Publisher · View at Google Scholar · View at Scopus
  21. L. A. Ormandy, T. Hillemann, H. Wedemeyer, M. P. Manns, T. F. Greten, and F. Korangy, “Increased populations of regulatory T cells in peripheral blood of patients with hepatocellular carcinoma,” Cancer Research, vol. 65, no. 6, pp. 2457–2464, 2005. View at Publisher · View at Google Scholar · View at Scopus
  22. L. Wang, Z. Q. Zou, and K. Wang, “Clinical relevance of HLA gene variants in HBV infection,” Journal of Immunology Research, vol. 2016, Article ID 9069375, 7 pages, 2016. View at Publisher · View at Google Scholar · View at Scopus
  23. S. W. Chang, C. S. Fann, W. H. Su et al., “A genome-wide association study on chronic HBV infection and its clinical progression in male Han-Taiwanese,” PloS One, vol. 9, no. 6, article e99724, 2014. View at Google Scholar
  24. S. Li, J. Qian, Y. Yang et al., “GWAS identifies novel susceptibility loci on 6p21.32 and 21q21.3 for hepatocellular carcinoma in chronic hepatitis B virus carriers,” PLoS Genetics, vol. 8, no. 7, article e1002791, 2012. View at Google Scholar
  25. D. K. Jiang, J. Sun, G. Cao et al., “Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma,” Nature Genetics, vol. 45, no. 1, pp. 72–75, 2013. View at Publisher · View at Google Scholar · View at Scopus