Association between HLA-DQ Gene Polymorphisms and HBV-Related Hepatocellular Carcinoma
Table 2
Main results of the meta-analysis of the association between HLA-DQ (rs2856718) polymorphisms and the risk of HBV-related HCC.
Comparison
Subgroup
OR (95% CI)
Model
Heterogeneity test
PZ
PE
I2 (%)
PH
HCC versus control
Dominant model (AG + GG versus AA)
Overall
0.54 (0.47–0.62)
F
0
0.688
<0.001
0.41
Chinese
0.53 (0.46–0.61)
F
0
0.990
<0.001
0.06
Saudi Arabian
0.74 (0.44–1.29)
0.294
Recessive model (GG versus AG + AA)
Overall
0.60 (0.51–0.70)
F
42.7
0.155
<0.001
0.51
Chinese
0.59 (0.50–0.69)
R
55.6
0.105
<0.001
0.22
Saudi Arabian
0.77 (0.43–1.35)
0.36
Homozygous model (GG versus AA)
Overall
0.44 (0.37–0.53)
F
23.2
0.271
<0.001
0.82
Chinese
0.43 (0.36–0.51)
F
13.7
0.314
<0.001
0.24
Saudi Arabian
0.67 (0.34–1.30)
0.24
Heterozygous model (AG versus AA)
Overall
0.59 (0.52–0.68)
F
0
0.704
<0.001
0.09
Chinese
0.58 (0.50–0.68)
F
0
0.841
<0.001
0.32
Saudi Arabian
0.80 (0.45–1.45)
0.46
Allele model (G versus A)
Overall
0.64 (0.58–0.70)
F
23.0
0.273
<0.001
0.88
Chinese
0.63 (0.57–0.69)
F
9.8
0.330
<0.001
0.22
Saudi Arabian
0.80 (0.50–1.14)
0.21
HCC versus CHB
Dominant model (AG + GG versus AA)
Overall
0.83 (0.63–1.10)
R
60.4%
0.056
0.194
0.308
Chinese
0.72 (0.62–0.83)
F
0
0.093
<0.001
0.283
Saudi Arabian
1. 53 (0.90–2.60)
0.112
Recessive model (GG versus AG + AA)
Overall
0.92 (0.78–1.09)
F
0
0.626
0.342
0.058
Chinese
0.94 (0.78–1.12)
F
0
0.511
0.485
0.251
Saudi Arabian
0.77 (0.44–1.36)
F
0
0.370
Homozygous model (GG versus AA)
Overall
0.79 (0.69–0.95)
F
0
0.676
0.014
0.982
Chinese
0.78 (0.63–0.93)
F
0
0.796
0.008
0.271
Saudi Arabian
1.09 (0.57–2.10)
F
0
0.787
Heterozygous model (AG versus AA)
Overall
0.90 (0.61–1.32)
R
75.9
0.006
0.579
0.245
Chinese
0.70 (0.60–0.81)
F
0
0.719
<0.001
0.281
Saudi Arabian
2.00 (1.12–3.58)
F
0
0.019
Allele model (G versus A)
Overall
0.85 (0.78–0.94)
F
0
0.486
0.001
0.707
Chinese
0.84 (0.76–0.92)
F
0
0.887
<0.001
0.229
Saudi Arabian
1.10 (0.77–1.56)
F
0
0.599
OR: odds ratio; CI: confidence interval; PH: value of heterogeneity test; PZ: value of Z test; PE: value of Egger’s test; R: random effect model; F: fixed effect model. Because there was only one study with this genotype of rs2856718, the value could not be calculated.
