Table of Contents Author Guidelines Submit a Manuscript
Gastroenterology Research and Practice
Volume 2017, Article ID 7407506, 16 pages
https://doi.org/10.1155/2017/7407506
Review Article

Platelet Count to Spleen Diameter Ratio for the Diagnosis of Gastroesophageal Varices in Liver Cirrhosis: A Systematic Review and Meta-Analysis

1Department of Gastroenterology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China
2Postgraduate College, Dalian Medical University, Dalian, China
3Department of Hospital Administration, Beijing University of Chinese Medicine, Beijing, China
4Department of Personnel, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China
5Department of Cardiology, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, China
6Department of Massage and Physiotherapy, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China

Correspondence should be addressed to Qian Shen; moc.361@441dbr

Received 3 September 2016; Accepted 30 November 2016; Published 8 February 2017

Academic Editor: Nianping Feng

Copyright © 2017 Runhua Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Platelet count to spleen diameter ratio (PSR) was studied extensively as a noninvasive method of diagnosis for varices. The present study aimed to systematically assess the performance of PSR in the diagnosis of varices. PubMed, EMBASE, and article references were searched. The summary receiver operating characteristic curves (AUSROCs), sensitivities, specificities, positive and negative likelihood ratio, and diagnostic odds ratio were calculated. The heterogeneity, quality, and publication bias of studies were evaluated. Subgroup and sensitivity analyses were performed. A total of 49 papers were included. The AUSROCs of PSR for any varices and high-risk varices were 0.8719 and 0.8132, respectively. The summary sensitivities of PSR for any varices and high-risk varices were 0.84 and 0.78, respectively. The summary specificities of PSR for any varices and high-risk varices were 0.78 and 0.67, respectively. The AUSROC of PSR for any varices at the threshold of 909 was 0.8867. The AUSROC of PSR for any varices in viral liver cirrhosis was 0.8675. The overall quality of studies was moderate. Significant heterogeneity and publication bias existed in the study. In conclusion, PSR can be used to identify varices in liver cirrhosis. PSR had a high sensitivity in viral liver cirrhosis.