Genetic Background and Clinical Characters of Pediatric Chronic Pancreatitis: Data and Implications from the East

Table 3

Comparison of juvenile ICP patients with or without the SPINK1 c.194+2T>C mutations.

	Juvenile patients carrying the; mutation ()	Juvenile patients without the; mutation ()	value
Age at onset (years, mean ± SD)	10.22 ± 2.91	10.56 ± 4.02	0.674
Female	19 (46.3%)	20 (65.2)	0.170
Clinical features
Type of pain attack			<0.001
RAP	29 (70.7%)	10 (31.3%)
RP	6 (14.6%)	2 (6.3%)
RAP/P	1 (2.4%)	11 (34.4%)
CPP	3 (7.3%)	8 (25.0%)
No pain attack	2 (4.9%)	1 (3.1%)
Jaundice	1 (2.4%)	0 (0.0%)	0.307
Pancreatic calcification	32 (78.0%)	26 (81.3%)	0.737
Complications
Pseudocyst	4 (9.8%)	3 (9.4%)	0.956
Diabetes mellitus	4 (9.8%)	0 (0%)	0.069
Steatorrhea	0 (0.00%)	0 (0.00%)	na

SPINK1, serine protease inhibitor Kazal type 1; SD, standard deviation; RAP, recurrent acute pancreatitis; RP, recurrent abdominal pain; RAP/P, recurrent acute pancreatitis or abdominal pain without significant increasing in serum amylase; CPP, chronic pancreatic pain.