Determination of Mammalian Target of Rapamycin Hyperactivation as Prognostic Factor in Well-Differentiated Neuroendocrine Tumors

Table 1

Demographics of study population.

Primary site	Pancreas	Gastrointestinal tract (ileum, stomach, and appendix)	Total
Number of pts	37	27	64 (M: 26)
Age median (range)	59.5 (30–79)	57 (21–78)	59 (21–79)
Syndrome	9 insulinoma	—	9 insulinoma
	1 carcinoid syndrome	2 carcinoid syndrome	3 carcinoid syndrome
	1 ZES	1 ZES	2 ZES
Stage	I-II: 22	I-II: 10	I-II: 32
	IIIB-IV: 15	IIIB-IV: 17	IIIB-IV: 32
Ki67 median (range)	1.8% (0.1–18.8%)	2.3% (0.5–12.4%)	1.8% (0.1–18.8%)
Grading	G1: 21 (56.8%)	G1: 18 (66.7%)	G1: 39 (60.9%)
	G2: 16 (43.2%)	G2: 9 (33.3%)	G2: 25 (39.1%)
Follow-up	Median 69.5 months (range: 4–140 months)

ZES: Zollinger-Ellison syndrome.