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Gastroenterology Research and Practice
Volume 2017, Article ID 9089068, 8 pages
https://doi.org/10.1155/2017/9089068
Research Article

Preoperative Serum IL-12p40 Is a Potential Predictor of Kasai Portoenterostomy Outcome in Infants with Biliary Atresia

1Department of Pediatric Hepatology, Gastroenterology and Nutrition, National Liver Institute, Menoufia University, Shebin El-Koom, Menoufia 32511, Egypt
2Department of Biochemistry, National Liver Institute, Menoufia University, Shebin El-Koom, Menoufia 32511, Egypt
3Department of Hepatobiliary Surgery, National Liver Institute, Menoufia University, Shebin El-Koom, Menoufia 32511, Egypt

Correspondence should be addressed to Mostafa Mohamed Sira; gro.ge-revil@arism

Received 22 January 2017; Accepted 16 April 2017; Published 15 May 2017

Academic Editor: Cristiano Pagnini

Copyright © 2017 Shaimaa Samy Goda et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The standard-of-care treatment for biliary atresia (BA) is surgical restoration of bile flow by Kasai portoenterostomy. We aimed to study serum interleukin- (IL-) 12p40, a natural antagonist for the proinflammatory IL-12p70, and its relation to surgical outcomes of BA. The study included 75 infants with neonatal cholestasis: BA group (), non-BA cholestasis group (), and neglected BA group (), in addition to thirty healthy neonates serving as controls. IL-12p40 was measured by ELISA in all individuals and a second assessment was performed 3 months postoperatively in the BA group. The surgical outcomes were classified as successful (bilirubin ≤ 2 mg/dl) or failed (bilirubin > 2 mg/dl). IL-12p40 was higher in BA compared to that in the non-BA and control groups ( values were 0.036 and <0.0001, resp.) but comparable to that in the neglected BA group. Preoperative IL-12p40 levels in BA patients were significantly higher in successful Kasai compared with failed Kasai and a cutoff level of 547.47 pg/ml could predict the successful outcome with 87.5% sensitivity and 82.4% specificity. Three-month postoperative IL-12p40 tended to decrease in both the successful and failed groups. In conclusion, preoperative serum IL-12p40 is a potential predictor of Kasai outcome. Serial postoperative measurements may anticipate the failure of an initially successful operation, hence the need for liver transplantation.