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Gastroenterology Research and Practice
Volume 2017, Article ID 9212143, 7 pages
https://doi.org/10.1155/2017/9212143
Research Article

Influence of Dietary Factors on Helicobacter pylori and CagA Seroprevalence in Bulgaria

1Department of Medical Microbiology, Medical University of Sofia, Sofia, Bulgaria
2Department of Social Medicine and Healthcare Management, Medical University of Sofia, Sofia, Bulgaria
3Centre of Transfusion Hematology, “St. Anna” University Hospital, Sofia, Bulgaria

Correspondence should be addressed to Rumyana Markovska; gb.vba@37aksvokram

Received 19 January 2017; Revised 24 March 2017; Accepted 15 May 2017; Published 4 June 2017

Academic Editor: Tatsuya Toyokawa

Copyright © 2017 Daniel Yordanov et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The aim of this study was to assess the association between some dietary factors and prevalence of H. pylori infection or strain virulence in 294 adult asymptomatic blood donors. Methods. Seroprevalence was evaluated using ELISA. Logistic regression was used. Results. Anti-H. pylori IgG prevalence was 72.4%, and CagA IgG seroprevalence was 49.3%. In the multivariate analyses, the frequent (>5 days per week) honey consumption was associated with both reduced H. pylori seroprevalence OR, 0.68 with 95% confidence interval (CI), 0.473–0.967 and reduced CagA IgG seroprevalence OR, 0.65 with 95% CI, 0.486–0859. Frequent (>5 days per week) yoghurt consumption also was associated with lower H. pylori virulence of the strains (CagA IgG OR, 0.56 with 95% CI, 0.341–0.921). Smoking and consumption of the other dietary factors resulted in no significant differences in the prevalence of H. pylori IgG and CagA IgG within the subject groups. Conclusion. To the best of our knowledge, this is the first report revealing reverse associations between honey or yoghurt consumption and CagA IgG prevalence as well as between frequent honey consumption and lower prevalence of the H. pylori infection. Regular honey and yoghurt consumption can be of value as a supplement in the control of H. pylori therapy.