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Gastroenterology Research and Practice
Volume 2017, Article ID 9865963, 8 pages
Review Article

A Meta-Analysis and Systematic Review of the Efficacy of Twice Daily PPIs versus Once Daily for Treatment of Gastroesophageal Reflux Disease

1State Key Laboratory of Cancer Biology & Institute of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi 710032, China
2Department of Intensive Care Unit, Shaanxi Provincial People’s Hospital, Xi’an, Shaanxi 710068, China

Correspondence should be addressed to Yongquan Shi; nc.ude.ummf@nauqyihs

Received 21 April 2017; Accepted 25 July 2017; Published 22 August 2017

Academic Editor: Yusuke Sato

Copyright © 2017 Hongying Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. To investigate whether PPIs BID is superior to QD for treatment of GERD in a short time. Methods. We searched PubMed, Cochrane Library, Scopus, EMBASE, Ovid, EBSCO, and Web of Science databases (from 1998 to May 2016) to select RCTs, which compared the efficacy of PPIs BID versus QD for GERD. The primary outcomes were symptom relief or esophageal mucosal healing at weeks 4 and 8. The M-H method with fixed-effect or random-effect model was used to calculate RR and 95% CIs. Results. Seven RCTs were enrolled. The esophageal healing rates were higher in PPIs BID group (), and rabeprazole 20 mg BID can achieve better mucosal healing than 20 mg QD after 8 weeks (). However, no significant differences were observed in heartburn relief (), sustained symptom relief rates at week 4 (), 24 h pH monitoring after treatment (), endoscopic response at week 4 (), and adverse events (). Conclusion. PPIs BID more effectively improve endoscopic healing rate at week 8 than PPIs QD. But there are no significant differences in symptom relief, 24 h pH monitoring, sustained symptom relief, and endoscopic response at week 4.