Screening Biomarker as an Alternative to Endoscopy for the Detection of Early Gastric Cancer: The Combination of Serum Trefoil Factor Family 3 and Pepsinogen

Table 2

Evaluation of patients with early gastric cancer using pepsinogen and TFF3 levels.

	TFF3 (−)	TFF3 (+)	Total
Derivation cohort
Pepsinogen test (−)	35 (20.6%)	135 (79.4%)	170
Pepsinogen test (+)	20 (18.0%)	91 (82.0%)	111
Total	55	226	281
Validation cohort
Pepsinogen test (−)	3 (15.0%)	17 (85.0%)	20
Pepsinogen test (+)	3 (30.0%)	7 (70.0%)	10
Total	6	24	30

TFF3: trefoil factor family 3. Serum pepsinogen test (+): pepsinogen I < 70 ng/mL and pepsinogen I/II ratio < 3.