Effects of Vonoprazan Compared with Esomeprazole on the Healing of Artificial Postendoscopic Submucosal Dissection Ulcers: A Prospective, Multicenter, Two-Arm, Randomized Controlled Trial

Figure 1

Patient flow chart. Sixty patients who gave written informed consent were randomly divided into two groups. All patients were given injections of 20 mg of omeprazole on the day of ESD and the next day. Oral administration of the test medications commenced on day 2 after ESD. Ulcer areas were evaluated via upper endoscopy on the next day and 4 weeks and 8 weeks after ESD, respectively.