Exenatide Delays the Progression of Nonalcoholic Fatty Liver Disease in C57BL/6 Mice, Which May Involve Inhibition of the NLRP3 Inflammasome through the Mitophagy Pathway

Figure 4

Effect of Exe on the NLRP3 inflammasome and IL-1β after four weeks of treatment. Effect of Exe on the expression of (a) NLRP3 and (b) IL-1β in the livers, as determined by Western blot. (c) The expression of NLRP3 in liver tissues, as shown by immunohistochemical staining of liver tissues. The positive staining for NLRP3 expression appears as brown-yellow granules. Representative Western blot and immunohistochemical images from each group were shown. Data are expressed as (n = 5-6). , model versus control group; and , Exe versus model group. Exe: exenatide; GADPH: glyceraldehyde 3-phosphate dehydrogenase.

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