Pattern of the First Recurrence Has No Impact on Long-Term Survival after Curative Intent Surgery for Perihilar Cholangiocarcinomas

Table 3

Studies from the literature assessing the recurrence pattern after curative intent surgery for perihilar cholangiocarcinomas.

Author, year	Number of patients resected for PHC	Median follow-uptime (months)	Median disease-freesurvival (months)	Overall recurrence observed during follow-up time (%)	Recurrence rate at 5 years	Isolated local recurrence rate (%)	Distant metastases at the first recurrence (%)	Death observed during follow-uptime (%)	Recurrence as cause of death (% of total deaths)
Jarnagin et al. [11], 2003	76	24 months	NA	68%	NA	NA	36%	NA	NA
Ito et al. [10], 2008	38	29 months	31 months	65.8%	NA	NA	42.1%	NA	NA
Chen et al. [8], 2009	138	33 months	NA	49.3%	NA	NA	45.7%	NA	NA
Kobayashi et al. [14], 2010	79	30 months	NA	53%	NA	NA	43%	NA	NA
Saxena et al. [15], 2011	42	20 months	15 months	64%	88%	NA	NA	60%	NA
Wahab et al. [22], 2012	159	27 months	NA	59.1%	NA	NA	NA	NA	NA
Nuzzo et al. [21], 2012, multicentric	440	NA	NA	54.5%	NA	NA	NA	NA	NA
Groot et al. [9], 2015, multicentric	306	48 months	26 months	58%	67%	18%	40%	70%	91%
Kang et al. [13], 2016	260	102 months	NA	55%	NA	NA	39.7%	NA	NA
Komaya et al. [7], 2018	402	43 months	NA	61.7%	71.4%	19.1%	45.8%	64.9%	NA
Zhang et al. [17], 2018, multicentric	225	18 months	NA	44%	70.5%	NA	NA	NA	NA
Present series, 2018	139	89 months	21 months	61.9%	68%	2.2%	59.7%	71.9%	83%