Review Article

Efficacy and Safety of Argon Plasma Coagulation for Hemorrhagic Chronic Radiation Proctopathy: A Systematic Review

Table 3

Study characteristics of selected studies on short-term and long-term complications after APC treatment.

AuthorProctitisTotal number of bleedingShort-term complicationsNumber of perforationsLong-term complicationsRate of complications (%)

AlfadhliProspective142 (vomiting, abdominal cramps, rectal pain, and fever)0014.30
Álvaro-VillegasChronic radiation proctitis142 (rectal pain)03 (rectal ulcers)35.70
BenHemorrhagic radiation proctitis275 (anal or rectal pain, vagal symptoms, and colonic explosions without perforation in 2 and perforation in 1)1018.50
CanardRadiation proctitis306 (post treatment pain)11 (extensive necrosis of the lower part of the rectum)26.70
Chruscielewska-KiliszekChronic radiation proctitis621 (adynamic ileus)035 (asymptomatic rectal ulcer in 30 and symptomatic rectal ulcers in 5)58.10
ChutkanProctitis120000.00
de la Serna HigueraHemorrhagic radiation proctopathy100000.00
DeesChronic radiation proctitis48001 (recurrence of rectal bleeding)2.00
FantinProctitis70000.00
Hortelano EChronic radiation proctitis301 (incontinence)01 (rectal ulcer)6.67
KaassisProctitis164 (transitory and minimal dysenteric)01 (recurrence of rectal bleeding)31.30
KaramanolisRadiation proctitis561 (colonic explosion without perforation)02 (recurrence of rectal bleeding)5.4
LatorreChronic radiation proctopathy38nana00.00
LenzChronic radiation coloproctopathy154 (anal pain in 2 cases and abdominal discomfort in 1, worsening of bleeding during treatment in 1)02 (tapered feces without stenosis in 1, asymptomatic stenosis in 1)40.00
LpoezRadiation proctopathy19001 (recurrence of rectal bleeding)5.30
OnoyamaChronic hemorrhagic radiation proctitis240000.00
Rolachon AProctitis and proctosigmoiditis12003 (chronic rectal ulcerations in 2 cases and rectal stenosis in 1 case)25.00
RotondanoChronic radiation proctopathy245 (mild bloating, cramping, anal pain)01 (rectal stenosis)25.00
Sait DagRadiation proctitis214 (rectal pain and distension)01 (recurrence of rectal bleeding)23.80
SamyChronic proctitis23nana00.00
SarahProctitis11007 (rectal stenosis in 2 patients, ulceration in 1, asymptomatic superficial ulceration in 4)63.60
SatoHemorrhagic radiation proctopathy658 (rectal pain)04 (recurrence of rectal bleeding)18.50
SebastianRadiation proctopathy250000.00
SilvaProctosigmoiditis283 (transient anal pain)0010.70
SmithProctitis70000.00
SwanChronic radiation proctitis4917 (proctalgia in 13 patients, rectal mucous discharge in 4, incontinence in 1, fever in 1, and bleeding in 1)01 (rectal stricture)36.00
TakemotoHemorrhagic radiation proctopathy120000.00
TamProctitis15002 (rectal stricture)13.30
TjandraHemorrhagic proctitis120000.00
VenkateshRadiation proctitis400000.00
VillavicencioHemorrhagic radiation proctopathy213 (rectal pain, tenesmus, and/or abdominal distention)01 (recurrence of rectal bleeding)19.00
ZinicolaRadiation proctitis12001 (rectosigmoid stenosis)7.10