Hemodynamic Evaluation of Nonselective β-Blockers in Patients with Cirrhosis and Refractory Ascites

Table 2

Intraindividual changes of hemodynamic parameters before and after LVP, while being on and off NSBB. Values are expressed as median (range). HR: heart rate; MAP: mean arterial pressure; CO: cardiac output; CI: cardiac index; SVR: systemic vascular resistance; PVR: peripheral vascular resistance; PRA: plasma renin activity. ^aPre-LVP versus pre-LVP with and without NSBB. ^bPost-LVP versus post-LVP with and without NSBB.

	Absence of NSBB			Presence of NSBB			value^a	value^b
	Pre-LVP	Post-LVP	value	Pre-LVP	Post-LVP	value	—
HR (bpm)	76 [68–94]	83 [76–89]	0.13	63 [55–73]	74 [60–85]	0.02	0.05	0.08
MAP (mmHg)	82 [71–103]	72 [68–86]	0.03	83 [60–96]	78 [58–85]	0.05	0.3	0.3
CO (l/min)	3.9 [2.8–4.8]	4.5 [3.7–4.9]	0.06	3.4 [3–3.9]	3.8 [3.5–4.1]	0.13	0.2	0.09
CI (l/min/m^2)	2.4 [2.1–2.9]	2.8 [2.1–3.1]	0.07	2.1 [2–2.5]	2.3 [2.1–2.9]	0.34	0.5	0.09
SVR (dyn·s·cm^−5)	1896 [1276–2293]	1348 [925–1804]	0.028	2002 [1609–2542]	1798 [1382–2863]	0.17	0.5	0.07
PVR (mmHg·min·dl·ml^−1)	47 [36–54]	30 [22–30]	0.04	49 [27–53]	36 [21–44]	0.2	0.8	0.09
PRA (ng·ml^−1·h^−1)	9.4 [5.3–14.2]	13 [6.4–16.9]	0.09	6.3 [4.8–9.6]	8.6 [4.9–11.6]	0.07	0.07	0.07