SHMT2 Overexpression Predicts Poor Prognosis in Intrahepatic Cholangiocarcinoma

Table 1

Relationship between SHMT2 expression and conventional clinicopathological parameters in human intrahepatic cholangiocarcinoma.

Clinicopathological parameters		SHMT2 expression		^∗
		Low	High
Gender				0.959
Female	31	15	16
Male	69	33	36
Age (years)				0.987
<60	52	25	27
≥60	48	23	25
Tumor size (cm)				0.935
≤5	40	19	21
>5	60	29	31
Tumor number				0.351
Solitary	91	45	46
Multiple	9	3	6
Vascular invasion				0.120
No	64	27	37
Yes	36	21	15
Pathological grade				0.361
I	4	3	1
II	62	27	35
III	34	18	16
T stage				0.017
T1	42	26	16
T2	47	20	27
T3–T4	11	2	9
N stage				0.318
N0	86	43	43
N1	14	5	9
Metastasis				0.261
No	96	45	51
Yes	4	3	1
TNM stage				0.041
I	34	22	12
II	42	18	24
III–IV	24	8	16