Predictive and Prognostic Implications of Mutation Profiling and Microsatellite Instability Status in Patients with Metastatic Colorectal Carcinoma

Figure 1

Set diagram illustrates the associations among KRAS, NRAS, HRAS, and BRAF mutations and MSI-H status. Mutations in KRAS and NRAS are not mutually exclusive, and neither are KRAS and BRAF. MSI-H status cooccurred with KRAS or BRAF mutations. MSI-H: microsatellite instability-high.