Predictive and Prognostic Implications of Mutation Profiling and Microsatellite Instability Status in Patients with Metastatic Colorectal Carcinoma

Table 1

Mutation subtype frequency distribution of RAS and BRAF genes.

Genes	Codon	Mutation	Cases (% of 461)
Total cases with RAS mutation			230 (49.9%)
Total cases with KRAS mutation			201 (43.6%)
KRAS	12	p.G12D	74 (16.1%)
	12	p.G12V	35 (7.6%)
	12	p.G12C	15 (3.3%)
	12	p.G12A	6 (1.3%)
	12	p.G12R	9 (1.9%)
	12	p.G12S	1 (0.2%)
	13	p.G13D	31 (6.7%)
	59	p.A59T	4 (0.9%)
	61	p.Q61H	2 (0.4%)
	146	p.A146T	16 (3.5%)
	146	p.A146V	3 (0.6%)
	Others	Others	5 (1.1%)
Total cases with NRAS mutation			13 (2.8%)
NRAS	12	p.G12D	4 (0.9%)
	12	p.G12S	2 (0.4%)
	18	p.A18T	1 (0.2%)
	61	p.Q61L	4 (0.9%)
	61	p.Q61R	2 (0.4%)
Total cases with HRAS mutation			1 (0.2%)
HRAS	12	p.G12D	1 (0.2%)
Total cases with BRAF mutation			26 (5.6%)
BRAF	600	V600E	26 (5.6%)