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Gastroenterology Research and Practice
Volume 2018, Article ID 4812703, 7 pages
Research Article

Prognostic Analysis of Duodenal Gastrointestinal Stromal Tumors

1Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
2Department of Cadre Ward, Fujian Medical Union Hospital, Fujian, China

Correspondence should be addressed to Zhengting Wang; moc.621@gnaw_ekad and Jie Zhong; moc.liamtoh@46jzymmij

Received 12 May 2017; Revised 1 September 2017; Accepted 10 September 2017; Published 20 February 2018

Academic Editor: Giovanni D. De Palma

Copyright © 2018 Liwen Hong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Aim. This study aims to analyze factors possibly related to the prognosis of duodenal gastrointestinal stromal tumors (DGISTs). Methods. We collected and retrospectively analyzed clinical and pathological data of 62 patients with primary DGISTs. All the patients were hospitalized and received complete surgical resection at Shanghai Ruijin Hospital from September 2003 to April 2015. We followed up the patients to determine survival outcomes. We also analyzed the effect of clinical and pathological factors on disease-free survival (DFS) and overall survival (OS) of the patients. Results. Kaplan-Meier univariate survival analysis demonstrated that tumor size, mitotic index, Ki-67 index, and pathological risk were correlated with the DFS and OS of the patients (DFS , 0.001, <0.001, and 0.005, resp.; OS , 0.007, <0.001, and 0.012, resp.). Cox multivariate regression analysis revealed that Ki-67 index was an independent prognostic factor affecting DFS and OS ( and 0.028, resp.). Moreover, Kaplan-Meier survival analysis showed that imatinib treatment for patients with recurrence was correlated with prolonged OS (). Conclusion. Prognosis for DGIST treated by R0 resection is favorable. High level of Ki-67 can be an independent risk factor of DGIST prognosis. Adjuvant imatinib therapy for patients with tumor recurrence could probably lead to prolonged survival.