Comparison of Concomitant Mesalamine and Immunomodulator Therapy and Immunomodulator Monotherapy for Crohn’s Disease

Table 2

Cox regression analysis for rescue therapy adjusting for various prognostic factors.

Variables	HR (95% CI)	value
Steroid rescue therapy
Age	0.959 (0.938–0.980)	<0.001
Gender
Female	1.315 (0.949–1.824)	0.100
Male
Previous intestinal resection
Yes	3.626 (1.650–7.969)	0.001
No
Previous steroid use
Yes	1.040 (0.616–1.755)	0.079
No
AZA/6-MP max. tolerable dose	0.548 (0.315–0.953)	0.033
Anti-TNF rescue therapy
Age	0.958 (0.930–0.987)	0.005
Gender
Female	1.575 (1.027–2.415)	0.037
Male
Previous intestinal resection
Yes	0.793 (0.108–5.817)	0.820
No
Previous steroid use
Yes	1.111 (0.746–1.656)	0.604
No
AZA/6-MP max. tolerable dose	0.385 (0.145–1.025)	0.046

AZA: azathioprine; 6-MP: 6-mercaptopurine; HR: hazard ratio; CI: confidence interval.