Diagnosis of Superficial Gastric Lesions Together with Six Gastric Lymphoma Cases via Probe-Based Confocal Laser Endomicroscopy: A Retrospective Observational Study

Figure 1

WLE and pCLE imaging of gastric lymphoma for case 1 (a–c, DLBCL), case 3 (d–f, MALT lymphoma), and case 6 (g–i, MALT lymphoma). The conventional endoscopic imaging revealed a single-nodule lesion with depressed surface in gastric body (a), multiple ulcerative lesions in gastric angular and antrum (d), and erosions and erythematous lesions in gastric angular (g). In the DLBCL case, pCLE revealed many dark and large roundish cells infiltrated widely in the exiting glands in a sheet-like fashion (b, c). In a MALT lymphoma case, pCLE revealed a massive infiltrate of small roundish cells with similar size and morphology, and in a dense arrangement (f, i), lymphoepithelial lesions could be observed (e, f, i). In (e), most pylorus glands were replaced by lymphocytic infiltrate except one gland showing the impaired structure infiltrated with small and roundish cells. In contrast, normal angular glands in the mucosa around the lesion in case 6 (h) showed regular oval or short rod-like pit pattern with homogenous epithelial cells.