Analysis of Prognostic Factors for Resected Synchronous and Metachronous Liver Metastases from Colorectal Cancer

Table 5

Multivariate analysis of factors associated with disease-free survival.

	value	HR	HR and 95% CI
Timing of metastases presentation/treatment	0.0008
Synchronous “combined surgery”	ref	ref	ref
Synchronous “bowel first”	0.219	1.9	0.7–5.5
Metachronous	0.067	0.5	0.2–1.1
ASA	0.005
1-2	ref	ref	ref
3	0.001	2.7	1.5–4.9
4	0.134	2.1	0.8–5.5
CHT before liver surgery	0.027
No	ref	ref	ref
Yes	0.027	2.5	1.1–5.6
CHT after liver surgery	0.028
No	ref	ref	ref
Yes	0.028	0.5	0.2–0.9

ref = reference; ASA = American Society of Anesthesiologists; CHT = chemotherapy.