Modern Endoscopic Imaging in Diagnosis and Surveillance of Inflammatory Bowel Disease Patients

Figure 2

Endomicroscopic imaging in Crohn’s disease and ulcerative colitis. Images (a) and (b) show endomicroscopic images provided by the integrated system (eCLE) with typical inflamed crypts and hypervascularization in Crohn’s colitis (a) and ulcerative colitis (b); arrowhead points towards vascular leakage. Pictograms (c) and (d) show endomicroscopic images provided by the probe-based system (pCLE) in a Crohn’s disease patient with colonic and ileal involvement (arrowhead in (c) shows a deformed crypt with lumen leakage; arrowhead in (d) shows a typical epithelial gap). (e) shows a premier molecular endomicroscopic imaging of golimumab FITC (ex vivo eCLE) in an ulcerative colitis patient that underwent proctocolectomy (arrowhead shows golimumab FITC-positive cells in the lamina propria, suggesting the high number and density of effector cells of inflammation).

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