Evaluating IL-21 as a Potential Therapeutic Target in Crohn’s Disease

Figure 10

Interventive treatment of AdTr mice with anti-IL-21 mAb. Open circles indicate individual anti-IL-21 mAb-treated mice, black squares indicate individual mIgG1-treated mice, and grey triangles indicate individual control SCID mice. Delta body weight change over time (days) (a). White blood cell count on days 21 and 34 (b). Frequency of CD4⁺TCRb⁺ T cells in blood on day 34 (c). Colon weight : length ratio (d). Endoscopic score encompassing (thickening of the colon, changes of vascular pattern, visible fibrin, granularity of mucosal surface, and stool consistency) on days 21, 34, and 47 (e).

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