Evaluating IL-21 as a Potential Therapeutic Target in Crohn’s Disease

Figure 12

Cytokine and chemokine profile in inflamed colon from mice treated with Anti-IL-21 mAb or mIgG1. Colon biopsies isolated from individual mice with AdTr colitis. Open circles anti-IL-21 25 mg/kg, black squares mIgG1, and grey triangles SCID controls. KC (a), CCL3 (b), CCL5 (c), IL-17 (d), TNFα (e), IFN-γ (f), CCL2 (g), and IP-10 (h) were found to be significantly downregulated in anti-IL-21 mAb-treated mice.

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